YRC Public Data Repository - Protein Structure Prediction

Protein:	LEP_PSEAE
Organism:	Pseudomonas aeruginosa PAO1
Length:	284 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LEP_PSEAE.

Description	E-value	Query Range	Subject Range
gi\|94418128, gi\|... - gi\|94418128\|ref\|ZP_01297944.1\| hypothetical protein PaerP_01000279 [Pseudomonas aeruginosa PA7], gi\|...	2.0E-88	[1..284]	[1..284]
LEP_PSEFL - Signal peptidase I OS=Pseudomonas fluorescens GN=lepB PE=3 SV=1	1.0E-87	[1..283]	[1..283]
gi\|84322715, gi\|... - gi\|84322715\|ref\|ZP_00970798.1\| COG0681: Signal peptidase I [Pseudomonas aeruginosa 2192], gi\|2542450...	8.0E-87	[1..284]	[1..284]
gi\|148549495, gi... - gi\|82739763\|ref\|ZP_00902552.1\| Peptidase S26A, signal peptidase I [Pseudomonas putida F1], gi\|827131...	2.0E-85	[1..284]	[1..284]
tr\|E4RHD6\|E4RHD6... - Signal peptidase I OS=Pseudomonas putida (strain BIRD-1) GN=lepB PE=3 SV=1 gi\|26988165, gi\|... - gi\|26988165\|ref\|NP_743590.1\| signal peptidase I [Pseudomonas putida KT2440], gi\|24982899\|gb\|AAN67054...	2.0E-85	[1..284]	[1..284]
gi\|71556075, gi\|... - gi\|71735522\|ref\|YP_276086.1\| signal peptidase I [Pseudomonas syringae pv. phaseolicola 1448A], gi\|71...	3.0E-85	[1..283]	[1..283]
gi\|63257887, gi\|... - gi\|66047180\|ref\|YP_237021.1\| Signal peptidase I [Pseudomonas syringae pv. syringae B728a], gi\|632578...	4.0E-85	[1..283]	[1..283]
gi\|95112251 - gi\|95112251\|emb\|CAK16978.1\| leader peptidase (signal peptidase I) , serine protease [Pseudomonas ent... gi\|95112251, gi\|... - gi\|95112251\|emb\|CAK16978.1\| leader peptidase (signal peptidase I) , serine protease [Pseudomonas ent...	5.0E-85	[1..284]	[1..284]
gi\|28871361, gi\|... - gi\|28871361\|ref\|NP_793980.1\| signal peptidase I [Pseudomonas syringae pv. tomato str. DC3000], gi\|28... tr\|Q87XF9\|Q87XF9... - Signal peptidase I OS=Pseudomonas syringae pv. tomato (strain DC3000) GN=lepB PE=3 SV=1	3.0E-84	[1..283]	[1..283]
gi\|70728452, gi\|... - gi\|70728452\|ref\|YP_258201.1\| signal peptidase I [Pseudomonas fluorescens Pf-5], gi\|68342751\|gb\|AAY90...	3.0E-84	[1..283]	[1..283]

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Predicted Domain #1

Region A:
Residues: [1-284]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTLNFPLLLV IAVAVCGALA LVDLVLFAPR RRAAISSYEG QVNEPDPAVL EKLNKEPLLV  60
   61 EYGKSFFPVL FIVLVLRSFL VEPFQIPSGS MKPTLEVGDF ILVNKFAYGI RLPVLDTKVI 120
  121 PIGDPQRGDV MVFRYPSEPN INYIKRVVGL PGDTVRYTKE KRLYVNGELV AEKLVGEEPG 180
  181 TLGSVTLYQE KLGQAEHLIR KEMSRYRIEP DRQWTIPAGH YFMMGDNRDN SNDSRYWNDP 240
  241 KIPKDLLGMV PDRNIVGKAF AVWMSWPDPK MSNLPNFSRV GVIH

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	52.39794
Match:	1t7dA
Description:	Crystal structure of Escherichia coli type I signal peptidase in complex with a lipopeptide inhibitor
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
peptidase activity	0.485843348899278	bayes_pls_golite062009
catalytic activity	0.415601732277814	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	0.237734983138449	bayes_pls_golite062009
hydrolase activity	0.188292586303013	bayes_pls_golite062009
protein binding	0.0579980138351139	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: