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View Structure Prediction Details

Protein: LCB5_YEAST
Organism: Saccharomyces cerevisiae S288c
Length: 687 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LCB5_YEAST.

Description E-value Query
Range
Subject
Range
LCB5_YEAST - Sphingoid long chain base kinase 5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=LCB5 ...
LCB5 - Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total ac...
0.0 [1..687] [1..687]
Sk1-PA, Sk1-PB - The gene Sphingosine kinase 1 is referred to in FlyBase by the symbol Dmel\Sk1 (CG1747, FBgn0030300)...
gi|220948786 - gi|220948786|gb|ACL86936.1| Sk1-PA [synthetic construct]
3.0E-83 [261..678] [181..641]
DGK1_ARATH - Diacylglycerol kinase 1 OS=Arabidopsis thaliana GN=DGK1 PE=1 SV=2
7.0E-80 [152..586] [224..683]
SPHK2_MOUSE - Sphingosine kinase 2 OS=Mus musculus GN=Sphk2 PE=1 SV=2
3.0E-78 [259..678] [136..613]
gi|119609799, gi... - gi|21361088|ref|NP_068807.2| sphingosine kinase 1 isoform 1 [Homo sapiens], gi|14495625|gb|AAH09419....
4.0E-77 [265..668] [25..371]

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Predicted Domain #1
Region A:
Residues: [1-201]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTLKPSKRRK GRSRHSRKKQ ITSAILTEEG IMIKAKPSSP YTYANRMADK RSRSSIDNIS  60
   61 RTSFQSNISR TSFQSNSDNN SIFETASLIS CVTCLSDTDT IDRSETSTTD TSKDDLSANP 120
  121 KLHYPSVNGQ LPANTVIPYG RILDARYIEK EPLHYYDANS SPSSPLSSSM SNISEKCDLD 180
  181 ELESSQKKER KGNSLSRGSN S

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [202-412]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSSLLTSRSP FTKLVEVIFA RPRRHDVVPK RVSLYIDYKP HSSSHLKEED DLVEEILKRS  60
   61 YKNTRRNKSI FVIINPFGGK GKAKKLFMTK AKPLLLASRC SIEVVYTKYP GHAIEIAREM 120
  121 DIDKYDTIAC ASGDGIPHEV INGLYQRPDH VKAFNNIAIT EIPCGSGNAM SVSCHWTNNP 180
  181 SYSTLCLIKS IETRIDLMCC SQPSYAREHP K

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 44.60206
Match: PF00781
Description: Diacylglycerol kinase catalytic domain (presumed)

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted functions:

Term Confidence Notes
kinase activity 0.697281815339077 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.541546416312833 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.416174911659548 bayes_pls_golite062009
catalytic activity 0.33446102778142 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [413-591]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LSFLSQTYGL IAETDINTEF IRWMGPARFE LGVAFNIIQK KKYPCEIYVK YAAKSKNELK  60
   61 NHYLEHKNKG SLEFQHITMN KDNEDCDNYN YENEYETENE DEDEDADADD EDSHLISRDL 120
  121 ADSSADQIKE EDFKIKYPLD EGIPSDWERL DPNISNNLGI FYTGKMPYVA ADTKFFPAA

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [592-687]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPSDGTMDMV ITDARTSLTR MAPILLGLDK GSHVLQPEVL HSKILAYKII PKLGNGLFSV  60
   61 DGEKFPLEPL QVEIMPRLCK TLLRNGRYVD TDFDSM

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.590 d.93.1 SH2 domain
View Download 0.464 b.1.2 Fibronectin type III
View Download 0.483 d.129.1 TATA-box binding protein-like
View Download 0.467 d.129.2 Phosphoglucomutase, C-terminal domain
View Download 0.452 d.146.1 Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain
View Download 0.436 d.129.1 TATA-box binding protein-like
View Download 0.435 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.432 a.46.1 Methionine synthase domain
View Download 0.431 a.118.11 Cytochrome c oxidase subunit E
View Download 0.428 d.129.1 TATA-box binding protein-like
View Download 0.403 a.74.1 Cyclin-like
View Download 0.398 c.58.1 Aminoacid dehydrogenase-like, N-terminal domain
View Download 0.394 d.212.1 TolA/TonB C-terminal domain
View Download 0.380 c.23.1 CheY-like
View Download 0.375 d.57.1 DNA damage-inducible protein DinI
View Download 0.373 d.58.7 RNA-binding domain, RBD
View Download 0.364 d.93.1 SH2 domain
View Download 0.357 a.60.9 lambda integrase-like, N-terminal domain
View Download 0.351 d.58.12 eEF-1beta-like
View Download 0.335 d.108.1 Acyl-CoA N-acyltransferases (Nat)
View Download 0.328 c.103.1 Hypothetical protein MT938 (MTH938)
View Download 0.306 d.58.49 YajQ-like
View Download 0.301 a.3.1 Cytochrome c
View Download 0.295 b.1.1 Immunoglobulin
View Download 0.283 d.141.1 Ribosomal protein L6
View Download 0.280 b.84.2 Rudiment single hybrid motif
View Download 0.277 b.36.1 PDZ domain-like
View Download 0.276 d.82.1 Copper amine oxidase, domain N
View Download 0.270 a.39.1 EF-hand
View Download 0.266 d.82.2 Frataxin-like
View Download 0.264 a.118.1 ARM repeat
View Download 0.258 c.15.1 BRCT domain
View Download 0.257 d.58.11 EF-G/eEF-2 domains III and V
View Download 0.256 d.45.1 ClpS-like
View Download 0.251 d.105.1 Clathrin adaptor appendage, alpha and beta chain-specific domain
View Download 0.248 d.49.1 Signal recognition particle alu RNA binding heterodimer, SRP9/14
View Download 0.241 c.59.1 MurD-like peptide ligases, peptide-binding domain
View Download 0.240 d.212.1 TolA/TonB C-terminal domain
View Download 0.226 a.4.8 Ribosomal protein S18
View Download 0.226 a.60.3 C-terminal domain of RNA polymerase alpha subunit
View Download 0.221 d.141.1 Ribosomal protein L6
View Download 0.217 d.109.1 Actin depolymerizing proteins
View Download 0.208 d.58.7 RNA-binding domain, RBD
View Download 0.205 d.58.23 Probable ACP-binding domain of malonyl-CoA ACP transacylase
View Download 0.205 d.58.27 Translational regulator protein regA
View Download 0.204 d.108.1 Acyl-CoA N-acyltransferases (Nat)
View Download 0.203 a.141.1 Frizzled cystein-rich domain


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