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View Structure Prediction Details

Protein: END3_YEAST
Organism: Saccharomyces cerevisiae S288c
Length: 349 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for END3_YEAST.

Description E-value Query
Range
Subject
Range
END3_YEAST - Actin cytoskeleton-regulatory complex protein END3 OS=Saccharomyces cerevisiae (strain ATCC 204508 /...
END3 - EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall ...
4.0E-55 [1..349] [1..349]
gi|3377791 - gi|3377791|gb|AAC28746.1| SAGA [Emericella nidulans]
5.0E-54 [3..339] [5..351]
EPS15L1 - epidermal growth factor receptor pathway substrate 15-like 1
2.0E-53 [2..348] [121..526]
gi|19577363 - gi|19577363|emb|CAD28444.1| probable SagA protein [Aspergillus fumigatus]
4.0E-52 [3..339] [5..351]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
1.0E-51 [3..345] [5..353]
gi|218195438 - gi|218195438|gb|EEC77865.1| hypothetical protein OsI_17131 [Oryza sativa Indica Group]
gi|38344274, gi|... - gi|38344274|emb|CAE03753.2| OSJNBa0013K16.2 [Oryza sativa (japonica cultivar-group)], gi|215692742|d...
2.0E-50 [38..283] [283..539]
CML12_ARATH - Calmodulin-like protein 12 OS=Arabidopsis thaliana GN=CML12 PE=1 SV=3
5.0E-50 [43..313] [11..294]

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Predicted Domain #1
Region A:
Residues: [1-98]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPKLEQFEIK KYWQIFSGLK PIENKVNHDQ VLPILYNSKL DSSVLNKIWF LADIDDDDNL  60
   61 DFEEFVICMR LIFDMVNKNI SSVPDELPDW LIPGSKVN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 128.156545
Match: 1eh2__
Description: Eps15
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [99-180]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LIKERKKRKQ IENADLPPKK EIKVDWYMSP DDLNQYEKIY NSCAKLTDGT ITFNELSTKL  60
   61 STKFFNISKT DLNKVWSLIN PQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.414 a.39.1 EF-hand
View Download 0.374 a.61.1 Retroviral matrix proteins
View Download 0.514 a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.514 a.4.3 ARID-like
View Download 0.407 a.60.5 Barrier-to-autointegration factor, BAF
View Download 0.371 a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.346 a.60.9 lambda integrase-like, N-terminal domain
View Download 0.342 a.4.1 Homeodomain-like
View Download 0.330 a.69.3 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain
View Download 0.327 a.2.11 Fe,Mn superoxide dismutase (SOD), N-terminal domain
View Download 0.300 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.293 a.4.13 Sigma3 and sigma4 domains of RNA polymerase sigma factors
View Download 0.291 a.4.5 "Winged helix" DNA-binding domain
View Download 0.287 a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.270 a.105.1 FIS-like
View Download 0.267 a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.260 a.3.1 Cytochrome c
View Download 0.256 a.36.1 Signal peptide-binding domain
View Download 0.256 a.60.8 HRDC-like
View Download 0.242 a.4.1 Homeodomain-like
View Download 0.240 a.3.1 Cytochrome c
View Download 0.218 d.54.1 Enolase N-terminal domain-like
View Download 0.218 a.118.1 ARM repeat
View Download 0.216 a.72.1 Functional domain of the splicing factor Prp18
View Download 0.204 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin

Predicted Domain #3
Region A:
Residues: [181-274]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NLPSIDRDPT FYFIHCLRQR NDLGAEIPAS LPNSLAEVCN KKQLSYDLRS SQPPTKRKEE  60
   61 ANEVDNLRDN GQNSSSDSSG SNVLSNEDSI KQKY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 38.221849
Match: 1iq5A_
Description: Calmodulin
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [275-349]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ASLTDDQVAN MREQLEGLLN YKKSEKTQGG SKLSKRINIR SITDDLDNIE QQVEVLENYL  60
   61 NNKRHELQAL QAEIN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.757 0.047 protein binding, bridging a.47.2 t-snare proteins
View Download 0.924 0.038 protein binding, bridging a.2.7 tRNA-binding arm
View Download 0.818 0.017 protein binding, bridging f.15.1 Small-conductance potassium channel
View Download 0.849 N/A N/A a.2.7 tRNA-binding arm
View Download 0.751 N/A N/A i.1.1 Ribosome and ribosomal fragments
View Download 0.730 N/A N/A a.151.1 Glutamyl tRNA-reductase dimerization domain
View Download 0.670 N/A N/A a.12.1 Kix domain of CBP (creb binding protein)
View Download 0.603 N/A N/A a.7.3 Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
View Download 0.572 N/A N/A a.2.3 Chaperone J-domain
View Download 0.560 N/A N/A f.34.1 Mechanosensitive channel protein MscS (YggB), transmembrane region
View Download 0.540 N/A N/A a.16.1 S15/NS1 RNA-binding domain
View Download 0.528 N/A N/A a.37.1 A DNA-binding domain in eukaryotic transcription factors
View Download 0.523 N/A N/A a.16.1 S15/NS1 RNA-binding domain
View Download 0.522 N/A N/A a.2.3 Chaperone J-domain
View Download 0.511 N/A N/A a.35.1 lambda repressor-like DNA-binding domains
View Download 0.491 N/A N/A a.7.8 GAT domain
View Download 0.468 N/A N/A a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View Download 0.461 N/A N/A a.24.3 Cytochromes
View Download 0.460 N/A N/A a.30.2 Homodimeric domain of signal transducing histidine kinase
View Download 0.431 N/A N/A a.7.5 Tubulin chaperone cofactor A
View Download 0.430 N/A N/A a.24.17 Group V grass pollen allergen
View Download 0.413 N/A N/A a.7.1 Spectrin repeat
View Download 0.413 N/A N/A a.22.1 Histone-fold
View Download 0.407 N/A N/A a.30.1 ROP protein
View Download 0.399 N/A N/A a.4.1 Homeodomain-like
View Download 0.388 N/A N/A a.2.8 Eukaryotic DNA topoisomerase I, dispensable insert domain
View Download 0.388 N/A N/A a.60.9 lambda integrase-like, N-terminal domain
View Download 0.380 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.376 N/A N/A a.4.1 Homeodomain-like
View Download 0.375 N/A N/A f.13.1 Family A G protein-coupled receptor-like
View Download 0.374 N/A N/A a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.373 N/A N/A a.64.1 Saposin
View Download 0.364 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.329 N/A N/A a.159.2 FF domain
View Download 0.317 N/A N/A a.2.2 Ribosomal protein L29 (L29p)
View Download 0.316 N/A N/A a.4.1 Homeodomain-like
View Download 0.314 N/A N/A a.24.7 FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View Download 0.309 N/A N/A a.4.1 Homeodomain-like
View Download 0.306 N/A N/A a.108.1 Ribosomal protein L7/12, oligomerisation (N-terminal) domain
View Download 0.300 N/A N/A a.159.1 Protein serine/threonine phosphatase 2C, C-terminal domain
View Download 0.299 N/A N/A a.112.1 Description not found.
View Download 0.293 N/A N/A a.2.10 Epsilon subunit of F1F0-ATP synthase C-terminal domain
View Download 0.291 N/A N/A a.139.1 Type I dockerin domain
View Download 0.290 N/A N/A f.17.1 F1F0 ATP synthase subunit C
View Download 0.281 N/A N/A a.5.2 UBA-like
View Download 0.280 N/A N/A a.29.4 RecG, N-terminal domain
View Download 0.276 N/A N/A a.64.1 Saposin
View Download 0.274 N/A N/A a.126.1 Serum albumin-like
View Download 0.274 N/A N/A a.8.2 Plasmid maintenance system epsilon/zeta, antidote epsilon subunit
View Download 0.272 N/A N/A g.57.1 Serine proteinase inhibitor lekti
View Download 0.268 N/A N/A d.58.49 YajQ-like
View Download 0.267 N/A N/A a.112.1 Description not found.
View Download 0.263 N/A N/A c.47.1 Thioredoxin-like
View Download 0.260 N/A N/A d.96.1 Tetrahydrobiopterin biosynthesis enzymes-like
View Download 0.256 N/A N/A f.30.1 Photosystem I reaction center subunit X, PsaK
View Download 0.252 N/A N/A a.60.6 DNA polymerase beta, N-terminal domain-like
View Download 0.241 N/A N/A d.104.1 Class II aaRS and biotin synthetases
View Download 0.232 N/A N/A f.16.1 Gated mechanosensitive channel
View Download 0.222 N/A N/A a.24.3 Cytochromes
View Download 0.222 N/A N/A a.30.2 Homodimeric domain of signal transducing histidine kinase
View Download 0.214 N/A N/A a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.214 N/A N/A a.2.1 GreA transcript cleavage protein, N-terminal domain
View Download 0.211 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.208 N/A N/A i.11.1 Computational models partly based on NMR data
View Download 0.207 N/A N/A a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.205 N/A N/A d.57.1 DNA damage-inducible protein DinI


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