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View Structure Prediction Details

Protein: PPID_YEAST
Organism: Saccharomyces cerevisiae S288c
Length: 371 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PPID_YEAST.

Description E-value Query
Range
Subject
Range
PPID_BOVIN - Peptidyl-prolyl cis-trans isomerase D OS=Bos taurus GN=PPID PE=1 SV=6
0.0 [2..371] [14..370]
gi|123996147, gi... - gi|123996147|gb|ABM85675.1| peptidylprolyl isomerase D (cyclophilin D) [synthetic construct], gi|123...
PPID - peptidylprolyl isomerase D
0.0 [2..371] [14..370]
PPID_MOUSE - Peptidyl-prolyl cis-trans isomerase D OS=Mus musculus GN=Ppid PE=1 SV=3
0.0 [3..371] [15..370]
CPR6 - Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide ...
PPID_YEAST - Peptidyl-prolyl cis-trans isomerase CPR6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN...
0.0 [1..371] [1..371]
CYP40_ARATH - Peptidyl-prolyl cis-trans isomerase CYP40 OS=Arabidopsis thaliana GN=CYP40 PE=2 SV=1
0.0 [1..370] [1..360]
PPID_NEUCR - 41 kDa peptidyl-prolyl cis-trans isomerase OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CB...
PPID_NEUCR - 41 kDa peptidyl-prolyl cis-trans isomerase OS=Neurospora crassa GN=cyp-41 PE=2 SV=1
0.0 [2..371] [10..375]
PPID_SCHPO - 40 kDa peptidyl-prolyl cis-trans isomerase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN...
wis2 - cyclophilin family peptidyl-prolyl cis-trans isomerase Wis2
2.0E-98 [1..370] [1..355]
gi|220944990, gi... - gi|220954904|gb|ACL89995.1| CG8336-PA [synthetic construct], gi|220944990|gb|ACL85038.1| CG8336-PA [...
CG8336-PB, CG833... - This gene is referred to in FlyBase by the symbol Dmel\CG8336 (CG8336, FBgn0036020). It is a protein...
2.0E-96 [2..371] [13..383]

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Predicted Domain #1
Region A:
Residues: [1-188]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTRPKTFFDI SIGGKPQGRI VFELYNDIVP KTAENFLKLC EGNAGMAKTK PDVPLSYKGS  60
   61 IFHRVIKDFM CQFGDFTNFN GTGGESIYDE KFEDENFTVK HDKPFLLSMA NAGPNTNGSQ 120
  121 AFITCVPTPH LDGKHVVFGE VIQGKRIVRL IENQQCDQEN NKPLRDVKID DCGVLPDDYQ 180
  181 VPENAEAT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 919.218487
Match: 1ihgA_
Description: Cyclophilin 40; Cyclophilin 40 isomerase domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein deacetylase activity 4.3775483906311 bayes_pls_golite062009
histone deacetylase activity 4.29026678196473 bayes_pls_golite062009
peptidyl-prolyl cis-trans isomerase activity 3.73853378771688 bayes_pls_golite062009
cis-trans isomerase activity 3.66963215732405 bayes_pls_golite062009
deacetylase activity 3.49940864924766 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 3.01511519120932 bayes_pls_golite062009
RNA binding 2.94609837984526 bayes_pls_golite062009
signal sequence binding 2.68460419248567 bayes_pls_golite062009
isomerase activity 1.96529188741504 bayes_pls_golite062009
binding 1.65866393331484 bayes_pls_golite062009
mRNA binding 1.45537055700871 bayes_pls_golite062009
unfolded protein binding 1.38124355054041 bayes_pls_golite062009
transcription regulator activity 1.26149030245805 bayes_pls_golite062009
peroxisome targeting sequence binding 1.01220052237687 bayes_pls_golite062009
DNA binding 0.9531600253493 bayes_pls_golite062009
nucleic acid binding 0.939772862764466 bayes_pls_golite062009
catalytic activity 0.748655649755714 bayes_pls_golite062009
hydrolase activity 0.493806105600863 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.408539130322443 bayes_pls_golite062009
transcription factor activity 0.374364600772076 bayes_pls_golite062009
drug binding 0.36339132904137 bayes_pls_golite062009
ubiquitin-protein ligase activity 0.322244688184474 bayes_pls_golite062009
small conjugating protein ligase activity 0.286133802341887 bayes_pls_golite062009
histone binding 0.268719695649015 bayes_pls_golite062009
protein binding 0.230077752280113 bayes_pls_golite062009
N-acetyltransferase activity 0.105969834846946 bayes_pls_golite062009
receptor binding 0.0640017685740477 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [189-283]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PTDEYGDNYE DVLKQDEKVD LKNFDTVLKA IETVKNIGTE QFKKQNYSVA LEKYVKCDKF  60
   61 LKEYFPEDLE KEQIEKINQL KVSIPLNIAI CALKL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 919.218487
Match: 1ihgA_
Description: Cyclophilin 40; Cyclophilin 40 isomerase domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [284-371]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KDYKQVLVAS SEVLYAEAAD EKAKAKALYR RGLAYYHVND TDMALNDLEM ATTFQPNDAA  60
   61 ILKAIHNTKL KRKQQNEKAK KSLSKMFS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 919.218487
Match: 1ihgA_
Description: Cyclophilin 40; Cyclophilin 40 isomerase domain
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle