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View Structure Prediction Details

Protein: NPC1_YEAST
Organism: Saccharomyces cerevisiae S288c
Length: 1170 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NPC1_YEAST.

Description E-value Query
Range
Subject
Range
gi|50978806, gi|... - gi|50978806|ref|NP_001003107.1| Niemann-Pick disease, type C1 [Canis lupus familiaris], gi|11878263|...
0.0 [1..1170] [8..1263]
NPC1 - Niemann-Pick disease, type C1
0.0 [1..1170] [8..1265]
NPC1_PIG - Niemann-Pick C1 protein OS=Sus scrofa GN=NPC1 PE=2 SV=1
0.0 [2..1170] [9..1264]
gi|20531742 - gi|20531742|gb|AAM27451.1| Niemann-Pick C1 [Felis catus]
0.0 [1..1170] [8..1263]
gi|6934272 - gi|6934272|gb|AAF31692.1|AF182744_1 Niemann-Pick type C1 protein [Cricetulus griseus]
0.0 [1..1170] [8..1264]
NCR1 - Vacuolar membrane protein that transits through the biosynthetic vacuolar protein sorting pathway, i...
gi|190407939 - gi|190407939|gb|EDV11204.1| transmembrane protein [Saccharomyces cerevisiae RM11-1a]
NPC1_YEAST - Niemann-Pick type C-related protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NC...
0.0 [1..1170] [1..1170]
gi|27807461, gi|... - gi|27807461|ref|NP_777183.1| Niemann-Pick disease, type C1 [Bos taurus], gi|10945625|gb|AAG24620.1|A...
0.0 [2..1170] [9..1264]
gi|30851359, gi|... - gi|32452030|gb|AAH54539.1| Niemann Pick type C1 [Mus musculus], gi|30851359|gb|AAH52437.1| Niemann P...
0.0 [1..1170] [8..1264]

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Predicted Domain #1
Region A:
Residues: [1-284]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNVLWIIALV GQLMRLVQGT ATCAMYGNCG KKSVFGNELP CPVPRSFEPP VLSDETSKLL  60
   61 VEVCGEEWKE VRYACCTKDQ VVALRDNLQK AQPLISSCPA CLKNFNNLFC HFTCAADQGR 120
  121 FVNITKVEKS KEDKDIVAEL DVFMNSSWAS EFYDSCKNIK FSATNGYAMD LIGGGAKNYS 180
  181 QFLKFLGDAK PMLGGSPFQI NYKYDLANEE KEWQEFNDEV YACDDAQYKC ACSDCQESCP 240
  241 HLKPLKDGVC KVGPLPCFSL SVLIFYTICA LFAFMWYYLC KRKK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [285-391]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NGAMIVDDDI VPESGSLDES ETNVFESFNN ETNFFNGKLA NLFTKVGQFS VENPYKILIT  60
   61 TVFSIFVFSF IIFQYATLET DPINLWVSKN SEKFKEKEYF DDNFGPF

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [490-547]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TNLLFSDDDI LNAHAFVVTL LLTNHTQSAN RWEERLEEYL LDLKVPEGLR ISFNTEIS

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [778-886]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LAVPQDSYLV DYFKDVYSFL NVGPPVYMVV KNLDLTKRQN QQKICGKFTT CERDSLANVL  60
   61 EQERHRSTIT EPLANWLDDY FMFLNPQNDQ CCRLKKGTDE VCPPSFPSR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 191.0103
Match: 1oy6A_
Description: Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains; Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains; Multidrug efflux transporter AcrB transmembrane domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [392-489]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YRTEQIFVVN ETGPVLSYET LHWWFDVENF ITEELQSSEN IGYQDLCFRP TEDSTCVIES  60
   61 FTQYFQGALP NKDSWKRELQ ECGKFPVNCL PTFQQPLK

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [548-777]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LEKELNNNND ISTVAISYLM MFLYATWALR RKDGKTRLLL GISGLLIVLA SIVCAAGFLT  60
   61 LFGLKSTLII AEVIPFLILA IGIDNIFLIT HEYDRNCEQK PEYSIDQKII SAIGRMSPSI 120
  121 LMSLLCQTGC FLIAAFVTMP AVHNFAIYST VSVIFNGVLQ LTAYVSILSL YEKRSNYKQI 180
  181 TGNEETKESF LKTFYFKMLT QKRLIIIIFS AWFFTSLVFL PEIQFGLDQT 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 191.0103
Match: 1oy6A_
Description: Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains; Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains; Multidrug efflux transporter AcrB transmembrane domain
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [887-977]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RCETCFQQGS WNYNMSGFPE GKDFMEYLSI WINAPSDPCP LGGRAPYSTA LVYNETSVSA  60
   61 SVFRTAHHPL RSQKDFIQAY SDGVRISSSF P

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [978-1170]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ELDMFAYSPF YIFFVQYQTL GPLTLKLIGS AIILIFFISS VFLQNIRSSF LLALVVTMII  60
   61 VDIGALMALL GISLNAVSLV NLIICVGLGV EFCVHIVRSF TVVPSETKKD ANSRVLYSLN 120
  121 TIGESVIKGI TLTKFIGVCV LAFAQSKIFD VFYFRMWFTL IIVAALHALL FLPALLSLFG 180
  181 GESYRDDSIE AED

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle