YRC Public Data Repository - Protein Structure Prediction

Protein:	HLDE_SALPC
Organism:	Salmonella enterica subsp. enterica serovar Paratyphi C strain RKS4594
Length:	477 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HLDE_SALPC.

Description	E-value	Query Range	Subject Range
HLDE_PHOLL - Bifunctional protein HldE OS=Photorhabdus luminescens subsp. laumondii (strain DSM 15139 / CIP 10556... HLDE_PHOLL - Bifunctional protein hldE OS=Photorhabdus luminescens subsp. laumondii GN=hldE PE=3 SV=1	3.0E-93	[1..473]	[1..473]
HLDE_ECO24 - Bifunctional protein HldE OS=Escherichia coli O139:H28 (strain E24377A / ETEC) GN=hldE PE=3 SV=1 gi\|194426262, gi... - gi\|75212315\|ref\|ZP_00712339.1\| COG2870: ADP-heptose synthase, bifunctional sugar kinase/adenylyltran... gi\|190901150, gi... - gi\|75227962\|ref\|ZP_00714657.1\| COG2870: ADP-heptose synthase, bifunctional sugar kinase/adenylyltran... gi\|192959254, gi... - gi\|75239377\|ref\|ZP_00723348.1\| COG2870: ADP-heptose synthase, bifunctional sugar kinase/adenylyltran... gi\|194436680, gi... - gi\|83587510\|ref\|ZP_00926137.1\| COG2870: ADP-heptose synthase, bifunctional sugar kinase/adenylyltran... HLDE_ECOL5 - Bifunctional protein HldE OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC) GN=hldE PE=3 SV=1 HLDE_ECOSE - Bifunctional protein HldE OS=Escherichia coli (strain SE11) GN=hldE PE=3 SV=1 HLDE_ECOSM - Bifunctional protein HldE OS=Escherichia coli (strain SMS-3-5 / SECEC) GN=hldE PE=3 SV=1 HLDE_ECO8A - Bifunctional protein HldE OS=Escherichia coli O8 (strain IAI1) GN=hldE PE=3 SV=1 HLDE_ECO27 - Bifunctional protein HldE OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=hldE PE=3 SV=1 HLDE_ECO7I - Bifunctional protein HldE OS=Escherichia coli O7:K1 (strain IAI39 / ExPEC) GN=hldE PE=3 SV=1 HLDE_ECO55 - Bifunctional protein HldE OS=Escherichia coli (strain 55989 / EAEC) GN=hldE PE=3 SV=1 HLDE_ECOLI - Bifunctional protein hldE [Includes: D-beta-D-heptose 7-phosphate kinase (EC 2.7.1.-) (D-beta-D-hept... gi\|124526037, gi... - gi\|124526037\|ref\|ZP_01698042.1\| rfaE bifunctional protein [Escherichia coli B], gi\|124502141\|gb\|EAY4... sp\|B7UIW0\|HLDE_ECO27 - Bifunctional protein hldE OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=hldE PE=3 SV=1 HLDE_ECOBW - Bifunctional protein HldE OS=Escherichia coli (strain K12 / MC4100 / BW2952) GN=hldE PE=3 SV=1 gi\|251786329, gi... - gi\|251786329\|ref\|YP_003000633.1\| hypothetical protein B21_02872 [Escherichia coli BL21], gi\|24237860... gi\|253979056, gi... - gi\|254289749\|ref\|YP_003055497.1\| fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransfer... gi\|254038219, gi... - gi\|254038219\|ref\|ZP_04872277.1\| hldE [Escherichia sp. 1_1_43], gi\|226839843\|gb\|EEH71864.1\| hldE [Esc... gi\|254162999, gi... - gi\|254162999\|ref\|YP_003046107.1\| fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransfer... HLDE_ECODH - Bifunctional protein HldE OS=Escherichia coli (strain K12 / DH10B) GN=hldE PE=3 SV=1 HLDE_ECOLC - Bifunctional protein HldE OS=Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks) GN=hldE PE=3 SV... gi\|192932382, gi... - gi\|75259985\|ref\|ZP_00731263.1\| COG2870: ADP-heptose synthase, bifunctional sugar kinase/adenylyltran... EG13416 - heptose 7-phosphate kinase and heptose 1-phosphate adenyltransferase / Heptose 7-P kinase /heptose 1-... gi\|188491309, gi... - gi\|75511264\|ref\|ZP_00733962.1\| COG2870: ADP-heptose synthase, bifunctional sugar kinase/adenylyltran... gi\|89109822, gi\|... - gi\|89109822\|ref\|AP_003602.1\| fused heptose 7-phosphate kinase and heptose 1-phosphate adenyltransfer... EG13416 - heptose 7-phosphate kinase and heptose 1-phosphate adenyltransferase / Heptose 7-P kinase /heptose 1-...	6.0E-93	[1..475]	[1..475]
HLDE_SHIFL - Bifunctional protein HldE OS=Shigella flexneri GN=hldE PE=3 SV=2 gi\|24053515, gi\|... - gi\|24114352\|ref\|NP_708862.1\| bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltrans...	7.0E-93	[1..475]	[1..475]
HLDE_ECOHS - Bifunctional protein HldE OS=Escherichia coli O9:H4 (strain HS) GN=hldE PE=3 SV=1	8.0E-93	[1..475]	[1..475]
gi\|188017774, gi... - gi\|188017774\|gb\|EDU55896.1\| bifunctional protein HldE [Escherichia coli O157:H7 str. EC4113], gi\|168... gi\|168754020, gi... - gi\|189358657\|gb\|EDU77076.1\| bifunctional protein HldE [Escherichia coli O157:H7 str. EC4401], gi\|168... gi\|13363408, gi\|... - gi\|15833189\|ref\|NP_311962.1\| bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltrans... gi\|15803594, gi\|... - gi\|15803594\|ref\|NP_289627.1\| bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltrans... gi\|209759382, gi... - pir\|\|F85965 probable kinase Z4405 [imported] - Escherichia coli (strain O157:H7, substrain EDL933),... gi\|208734396, gi... - gi\|208813119\|ref\|ZP_03254448.1\| bifunctional protein HldE [Escherichia coli O157:H7 str. EC4045], gi... gi\|208739909, gi... - gi\|208819786\|ref\|ZP_03260106.1\| bifunctional protein HldE [Escherichia coli O157:H7 str. EC4042], gi... HLDE_ECO5E - Bifunctional protein HldE OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=hldE PE=3 SV=1 gi\|217319269, gi... - gi\|217326902\|ref\|ZP_03442985.1\| bifunctional protein HldE [Escherichia coli O157:H7 str. TW14588], g... gi\|168785924, gi... - gi\|189374230\|gb\|EDU92646.1\| bifunctional protein HldE [Escherichia coli O157:H7 str. EC869], gi\|1687... gi\|189379666, gi... - gi\|189379666\|gb\|EDU98082.1\| bifunctional protein HldE [Escherichia coli O157:H7 str. EC508], gi\|1687... HLDE_ECO57 - Bifunctional protein HldE OS=Escherichia coli O157:H7 GN=hldE PE=3 SV=1 gi\|195937196 - gi\|195937196\|ref\|ZP_03082578.1\| bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltr... gi\|208726297, gi... - gi\|208806496\|ref\|ZP_03248833.1\| bifunctional protein HldE [Escherichia coli O157:H7 str. EC4206], gi... gi\|254795003, gi... - gi\|254795003\|ref\|YP_003079840.1\| bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenylt... gi\|168760211, gi... - gi\|189369293\|gb\|EDU87709.1\| bifunctional protein HldE [Escherichia coli O157:H7 str. EC4501], gi\|168... gi\|168767073, gi... - gi\|189363861\|gb\|EDU82280.1\| bifunctional protein HldE [Escherichia coli O157:H7 str. EC4486], gi\|168... gi\|168773293, gi... - gi\|187770866\|gb\|EDU34710.1\| bifunctional protein HldE [Escherichia coli O157:H7 str. EC4196], gi\|168... gi\|168781926, gi... - gi\|189000647\|gb\|EDU69633.1\| bifunctional protein HldE [Escherichia coli O157:H7 str. EC4076], gi\|168...	9.0E-93	[1..475]	[1..475]
HLDE_SHISS - Bifunctional protein HldE OS=Shigella sonnei (strain Ss046) GN=hldE PE=3 SV=1	1.0E-92	[1..475]	[1..475]
HLDE_SHIF8 - Bifunctional protein HldE OS=Shigella flexneri serotype 5b (strain 8401) GN=hldE PE=3 SV=1 gi\|30064400, gi\|... - gi\|30064400\|ref\|NP_838571.1\| bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltrans...	1.0E-92	[1..475]	[1..475]
HLDE_SHIBS - Bifunctional protein HldE OS=Shigella boydii serotype 4 (strain Sb227) GN=hldE PE=3 SV=1 HLDE_SHIB3 - Bifunctional protein HldE OS=Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) GN=hldE PE=3 S...	1.0E-92	[1..475]	[1..475]
gi\|126207886, gi... - gi\|126207886\|ref\|YP_001053111.1\| bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenylt... gi\|32034719 - gi\|32034719\|ref\|ZP_00134850.1\| COG2870: ADP-heptose synthase, bifunctional sugar kinase/adenylyltran...	2.0E-92	[1..475]	[2..476]
HLDE_SHIDS - Bifunctional protein HldE OS=Shigella dysenteriae serotype 1 (strain Sd197) GN=hldE PE=3 SV=1	2.0E-92	[1..475]	[1..475]

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Predicted Domain #1

Region A:
Residues: [1-319]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKVNLPAFER AGVMVVGDVM LDRYWYGPTC RISPEAPVPV VKVNTVEERP GGAANVAMNI  60
   61 ASLGANARLV GLTGIDDAAR ALSKTLAEVN VKCDFVSVPT HPTITKLRVL SRNQQLIRLD 120
  121 FEEGFEGVDP QPLHERINQA LGSIGALVLS DYAKGALTSV QTMISLARQA GVPVLIDPKG 180
  181 TDFERYRGAT LLTPNLSEFE AVAGKCKSED ELVERGMKLI ADYDLSALLV TRSEQGMTLL 240
  241 QPNKAPLHMP TQAQEVYDVT GAGDTVIGVL AATLAAGNTL EEACYFANAA AGVVVGKLGT 300
  301 STVSPIELEN AVRGRADTG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	45.30103
Match:	1vm7A
Description:	Crystal structure of Ribokinase (TM0960) from Thermotoga maritima at 2.15 A resolution
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ribokinase activity	4.25786236481087	bayes_pls_golite062009
catalytic activity	2.11518580948187	bayes_pls_golite062009
carbohydrate kinase activity	1.99025603598964	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.69918601153494	bayes_pls_golite062009
transferase activity	1.65599843675995	bayes_pls_golite062009
kinase activity	1.6060752218324	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.143446029424335	bayes_pls_golite062009
phosphofructokinase activity	0.0784945911925501	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [320-477]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FGVMTEEELR QAVASARKRG EKVVMTNGVF DILHAGHVSY LANARKLGDR LIVAVNSDAS  60
   61 TKRLKGESRP VNPLEQRMIV LGALESVDWV VSFEEDTPQR LIAGILPDLL VKGGDYKPEE 120
  121 IAGSEEVWAN GGEVMVLNFE DGCSTTNIIK KIQTESEK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	27.522879
Match:	1cozA
Description:	CTP:glycerol-3-phosphate cytidylyltransferase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	2.74718220535323	bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds	2.19141941108903	bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds	2.19141941108903	bayes_pls_golite062009
aminoacyl-tRNA ligase activity	2.17852738923841	bayes_pls_golite062009
ligase activity	1.15322915814026	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: