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View Structure Prediction Details

Protein: gi|213427860
Organism: Salmonella enterica subsp. enterica serovar Typhi str. E02-1180
Length: 482 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|213427860.

Description E-value Query
Range
Subject
Range
THII_SALCH - tRNA sulfurtransferase OS=Salmonella choleraesuis (strain SC-B67) GN=thiI PE=3 SV=1
THII_SALCH - Thiamine biosynthesis protein thiI OS=Salmonella choleraesuis GN=thiI PE=3 SV=1
THII_SALCH - tRNA sulfurtransferase OS=Salmonella choleraesuis GN=thiI PE=3 SV=1
3.0E-98 [1..482] [1..482]
gi|204926685, gi... - gi|204926685|ref|ZP_03217887.1| thiamine biosynthesis/tRNA modification protein ThiI [Salmonella ent...
THII_SALPK - tRNA sulfurtransferase OS=Salmonella paratyphi A (strain AKU_12601) GN=thiI PE=3 SV=1
gi|197266005, gi... - gi|197266005|ref|ZP_03166079.1| thiamine biosynthesis/tRNA modification protein ThiI [Salmonella ent...
THII_SALPA - tRNA sulfurtransferase OS=Salmonella paratyphi A GN=thiI PE=3 SV=1
THII_SALA4 - tRNA sulfurtransferase OS=Salmonella agona (strain SL483) GN=thiI PE=3 SV=1
THII_SALSV - tRNA sulfurtransferase OS=Salmonella schwarzengrund (strain CVM19633) GN=thiI PE=3 SV=1
gi|168237538, gi... - gi|197289454|gb|EDY28817.1| thiamine biosynthesis/tRNA modification protein ThiI [Salmonella enteric...
gi|238911442 - gi|238911442|ref|ZP_04655279.1| thiamine biosynthesis protein ThiI [Salmonella enterica subsp. enter...
THII_SALPA - tRNA sulfurtransferase OS=Salmonella paratyphi A (strain ATCC 9150 / SARB42) GN=thiI PE=3 SV=1
3.0E-98 [1..482] [1..482]
gi|209743998, gi... - pir||A85539 probable oxidoreductase yajK [imported] - Escherichia coli (strain O157:H7, substrain E...
gi|254591007, gi... - gi|254791607|ref|YP_003076444.1| sulfur transfer protein [Escherichia coli O157:H7 str. TW14359], gi...
gi|15800153, gi|... - gi|15800153|ref|NP_286165.1| thiamine biosynthesis protein ThiI [Escherichia coli O157:H7 EDL933], g...
gi|208808957, gi... - gi|208808957|ref|ZP_03251294.1| thiamine biosynthesis/tRNA modification protein ThiI [Escherichia co...
gi|195938510 - gi|195938510|ref|ZP_03083892.1| thiamine biosynthesis protein ThiI [Escherichia coli O157:H7 str. EC...
THII_ECO57 - tRNA sulfurtransferase OS=Escherichia coli O157:H7 GN=thiI PE=1 SV=1
gi|168800306, gi... - gi|189377419|gb|EDU95835.1| thiamine biosynthesis/tRNA modification protein ThiI [Escherichia coli O...
gi|189373595, gi... - gi|189373595|gb|EDU92011.1| thiamine biosynthesis/tRNA modification protein ThiI [Escherichia coli O...
gi|217325977, gi... - gi|217325977|ref|ZP_03442061.1| thiamine biosynthesis/tRNA modification protein ThiI [Escherichia co...
THII_ECO5E - tRNA sulfurtransferase OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=thiI PE=3 SV=1
gi|208822980, gi... - gi|208822980|ref|ZP_03263298.1| thiamine biosynthesis/tRNA modification protein ThiI [Escherichia co...
gi|208731895, gi... - gi|208815247|ref|ZP_03256426.1| thiamine biosynthesis/tRNA modification protein ThiI [Escherichia co...
gi|189356012, gi... - gi|189356012|gb|EDU74431.1| thiamine biosynthesis/tRNA modification protein ThiI [Escherichia coli O...
gi|168749885, gi... - gi|188015859|gb|EDU53981.1| thiamine biosynthesis/tRNA modification protein ThiI [Escherichia coli O...
gi|188999332, gi... - gi|188999332|gb|EDU68318.1| thiamine biosynthesis/tRNA modification protein ThiI [Escherichia coli O...
gi|187768273, gi... - gi|187768273|gb|EDU32117.1| thiamine biosynthesis/tRNA modification protein ThiI [Escherichia coli O...
gi|13359934, gi|... - gi|15829731|ref|NP_308504.1| thiamine biosynthesis protein ThiI [Escherichia coli O157:H7 str. Sakai...
gi|189362457, gi... - gi|189362457|gb|EDU80876.1| thiamine biosynthesis/tRNA modification protein ThiI [Escherichia coli O...
gi|189368047, gi... - gi|189368047|gb|EDU86463.1| thiamine biosynthesis/tRNA modification protein ThiI [Escherichia coli O...
4.0E-98 [1..482] [1..482]
lcl|NC_016856.1_... - [gene=thiI] [protein=thiamine biosynthesis protein ThiI] [protein_id=YP_005236118.1] [location=47856...
THII_SALTY - tRNA sulfurtransferase OS=Salmonella typhimurium GN=thiI PE=3 SV=2
THII_SALTY - Thiamine biosynthesis protein thiI OS=Salmonella typhimurium GN=thiI PE=3 SV=2
THII_SALTY - tRNA sulfurtransferase OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=thiI PE=3 ...
gi|205329560, gi... - gi|205329560|gb|EDZ16324.1| thiamine biosynthesis/tRNA modification protein ThiI [Salmonella enteric...
6.0E-98 [1..482] [1..482]
THII_PHOLL - tRNA sulfurtransferase OS=Photorhabdus luminescens subsp. laumondii (strain DSM 15139 / CIP 105565 /...
THII_PHOLL - tRNA sulfurtransferase OS=Photorhabdus luminescens subsp. laumondii GN=thiI PE=3 SV=1
9.0E-98 [1..482] [1..482]
gi|194432608, gi... - gi|83570309|ref|ZP_00921754.1| COG0301: Thiamine biosynthesis ATP pyrophosphatase [Shigella dysenter...
1.0E-97 [1..482] [1..482]
EG13273 - tRNA s(4)U8 sulfurtransferase / tRNA s(4)U8 sulfurtransferase, activated by IscS; ThiS-thiocarboxyla...
THII_ECOLU - tRNA sulfurtransferase OS=Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC) GN=thiI PE=3 SV=1
THII_ECODH - tRNA sulfurtransferase OS=Escherichia coli (strain K12 / DH10B) GN=thiI PE=3 SV=1
gi|89107293, gi|... - gi|89107293|ref|AP_001073.1| sulfurtransferase required for thiamine and 4-thiouridine biosynthesis ...
EG13273 - tRNA s(4)U8 sulfurtransferase / tRNA s(4)U8 sulfurtransferase, activated by IscS; ThiS-thiocarboxyla...
THII_ECOLI - Thiamine biosynthesis protein thiI - Escherichia coli
THII_ECOBW - tRNA sulfurtransferase OS=Escherichia coli (strain K12 / MC4100 / BW2952) GN=thiI PE=3 SV=1
2.0E-97 [1..482] [1..482]
THII_SHIF8 - tRNA sulfurtransferase OS=Shigella flexneri serotype 5b (strain 8401) GN=thiI PE=3 SV=1
THII_SHIFL - tRNA sulfurtransferase OS=Shigella flexneri GN=thiI PE=3 SV=2
gi|30061917, gi|... - gi|30061917|ref|NP_836088.1| thiamine biosynthesis protein ThiI [Shigella flexneri 2a str. 2457T], g...
2.0E-97 [1..482] [1..482]
THII_SHIDS - tRNA sulfurtransferase OS=Shigella dysenteriae serotype 1 (strain Sd197) GN=thiI PE=3 SV=1
2.0E-97 [1..482] [1..482]
THII_SHISS - tRNA sulfurtransferase OS=Shigella sonnei (strain Ss046) GN=thiI PE=3 SV=1
2.0E-97 [1..482] [1..482]

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Predicted Domain #1
Region A:
Residues: [1-367]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKFIIKLFPE ITIKSQSVRL RFIKILTGNI RNVLKHYDET LAVVRHWDNI EVRAKDENQR  60
   61 LAIRDALTRI PGIHHILEVE DVPFTDMHDI FEKALAQYRE QLEGKTFCVR VKRRGKHEFS 120
  121 SIEVERYVGG GLNQHIESAR VKLTNPDVTV HLEVEDDRLL LIKGRYEGIG GFPIGTQEDV 180
  181 LSLISGGFDS SVSSYMLMRR GCRVHYCFFN LGGAAHEIGV RQVAHYLWNR FGSSHRVRFV 240
  241 AINFEPVVGE ILEKVDDGQM GVVLKRMMVR AASKVAERYG VQALVTGEAL GQVSSQTLTN 300
  301 LRLIDNVSDT LILRPLISYD KEHIINLARQ IGTEDFARTM PEYCGVISKS PTVKAIKAKI 360
  361 EAEEENF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 67.522879
Match: 2c5sA
Description: Crystal structure of Bacillus anthracis ThiI, a tRNA-modifying enzyme containing the predicted RNA-binding THUMP domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
catalytic activity 0.735352182450617 bayes_pls_golite062009
ligase activity 0.249728764626579 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 0.196167461233561 bayes_pls_golite062009
NAD+ synthase (glutamine-hydrolyzing) activity 0.1036205758202 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [368-482]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DFSILDKVVE EANNVDIREI AQQTQQEVVE VETVSGFGAN DVILDIRSVD EQDDKPLKVE  60
   61 GVDVVSLPFY KLSTKFGDLD QSKTWLLWCE RGVMSRLQAL YLREQGFANV KVYRP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 36.0
Match: 1gpmA
Description: GMP synthetase; GMP synthetase, central domain; GMP synthetase C-terminal dimerisation domain
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle