YRC Public Data Repository - Protein Structure Prediction

Protein:	HLDE_ECO8A
Organism:	Escherichia coli IAI1
Length:	477 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HLDE_ECO8A.

Description	E-value	Query Range	Subject Range
gi\|126207886, gi... - gi\|126207886\|ref\|YP_001053111.1\| bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenylt... gi\|32034719 - gi\|32034719\|ref\|ZP_00134850.1\| COG2870: ADP-heptose synthase, bifunctional sugar kinase/adenylyltran...	407.0	[0..6]	[475..7]
HLDE_ACTPL - Bifunctional protein HldE OS=Actinobacillus pleuropneumoniae GN=hldE PE=3 SV=1	406.0	[0..6]	[475..6]
gi\|188017774, gi... - gi\|188017774\|gb\|EDU55896.1\| bifunctional protein HldE [Escherichia coli O157:H7 str. EC4113], gi\|168... gi\|168754020, gi... - gi\|189358657\|gb\|EDU77076.1\| bifunctional protein HldE [Escherichia coli O157:H7 str. EC4401], gi\|168... gi\|13363408, gi\|... - gi\|15833189\|ref\|NP_311962.1\| bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltrans... gi\|15803594, gi\|... - gi\|15803594\|ref\|NP_289627.1\| bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltrans... gi\|209759382, gi... - pir\|\|F85965 probable kinase Z4405 [imported] - Escherichia coli (strain O157:H7, substrain EDL933),... gi\|208734396, gi... - gi\|208813119\|ref\|ZP_03254448.1\| bifunctional protein HldE [Escherichia coli O157:H7 str. EC4045], gi... gi\|208739909, gi... - gi\|208819786\|ref\|ZP_03260106.1\| bifunctional protein HldE [Escherichia coli O157:H7 str. EC4042], gi... HLDE_ECO5E - Bifunctional protein HldE OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=hldE PE=3 SV=1 gi\|217319269, gi... - gi\|217326902\|ref\|ZP_03442985.1\| bifunctional protein HldE [Escherichia coli O157:H7 str. TW14588], g... gi\|168785924, gi... - gi\|189374230\|gb\|EDU92646.1\| bifunctional protein HldE [Escherichia coli O157:H7 str. EC869], gi\|1687... gi\|189379666, gi... - gi\|189379666\|gb\|EDU98082.1\| bifunctional protein HldE [Escherichia coli O157:H7 str. EC508], gi\|1687... HLDE_ECO57 - Bifunctional protein HldE OS=Escherichia coli O157:H7 GN=hldE PE=3 SV=1 gi\|195937196 - gi\|195937196\|ref\|ZP_03082578.1\| bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltr... gi\|208726297, gi... - gi\|208806496\|ref\|ZP_03248833.1\| bifunctional protein HldE [Escherichia coli O157:H7 str. EC4206], gi... gi\|254795003, gi... - gi\|254795003\|ref\|YP_003079840.1\| bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenylt... gi\|168760211, gi... - gi\|189369293\|gb\|EDU87709.1\| bifunctional protein HldE [Escherichia coli O157:H7 str. EC4501], gi\|168... gi\|168767073, gi... - gi\|189363861\|gb\|EDU82280.1\| bifunctional protein HldE [Escherichia coli O157:H7 str. EC4486], gi\|168... gi\|168773293, gi... - gi\|187770866\|gb\|EDU34710.1\| bifunctional protein HldE [Escherichia coli O157:H7 str. EC4196], gi\|168... gi\|168781926, gi... - gi\|189000647\|gb\|EDU69633.1\| bifunctional protein HldE [Escherichia coli O157:H7 str. EC4076], gi\|168...	404.0	[0..1]	[477..1]
HLDE_ECOHS - Bifunctional protein HldE OS=Escherichia coli O9:H4 (strain HS) GN=hldE PE=3 SV=1	404.0	[0..1]	[477..1]
HLDE_SHIF8 - Bifunctional protein HldE OS=Shigella flexneri serotype 5b (strain 8401) GN=hldE PE=3 SV=1 gi\|30064400, gi\|... - gi\|30064400\|ref\|NP_838571.1\| bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltrans...	403.0	[0..1]	[477..1]
gi\|237706188, gi... - gi\|237706188\|ref\|ZP_04536669.1\| hldE [Escherichia sp. 3_2_53FAA], gi\|226899228\|gb\|EEH85487.1\| hldE [... HLDE_ECOUT - Bifunctional protein HldE OS=Escherichia coli (strain UTI89 / UPEC) GN=hldE PE=3 SV=1 HLDE_ECO81 - Bifunctional protein HldE OS=Escherichia coli O81 (strain ED1a) GN=hldE PE=3 SV=1 HLDE_ECOK1 - Bifunctional protein HldE OS=Escherichia coli O1:K1 / APEC GN=hldE PE=3 SV=1 HLDE_ECO45 - Bifunctional protein HldE OS=Escherichia coli O45:K1 (strain S88 / ExPEC) GN=hldE PE=3 SV=1 HLDE_ECOL6 - Bifunctional protein HldE OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) GN=hldE PE=... gi\|190907201, gi... - gi\|75240487\|ref\|ZP_00724415.1\| COG2870: ADP-heptose synthase, bifunctional sugar kinase/adenylyltran... HLDE_ECOL6 - Bifunctional protein hldE OS=Escherichia coli O6 GN=hldE PE=3 SV=1 gi\|227835168, gi... - gi\|227887772\|ref\|ZP_04005577.1\| bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltr...	403.0	[0..1]	[477..1]
HLDE_SHISS - Bifunctional protein HldE OS=Shigella sonnei (strain Ss046) GN=hldE PE=3 SV=1	403.0	[0..1]	[477..1]
HLDE_SHIDS - Bifunctional protein HldE OS=Shigella dysenteriae serotype 1 (strain Sd197) GN=hldE PE=3 SV=1	402.0	[0..1]	[477..1]
HLDE_SHIBS - Bifunctional protein HldE OS=Shigella boydii serotype 4 (strain Sb227) GN=hldE PE=3 SV=1 HLDE_SHIB3 - Bifunctional protein HldE OS=Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) GN=hldE PE=3 S...	402.0	[0..1]	[477..1]
HLDE_SHIFL - Bifunctional protein HldE OS=Shigella flexneri GN=hldE PE=3 SV=2 gi\|24053515, gi\|... - gi\|24114352\|ref\|NP_708862.1\| bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltrans...	401.0	[0..1]	[477..1]

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Predicted Domain #1

Region A:
Residues: [1-322]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKVTLPEFER AGVMVVGDVM LDRYWYGPTS RISPEAPVPV VKVNTIEERP GGAANVAMNI  60
   61 ASLGANARLV GLTGIDDAAR ALSKSLADVN VKCDFVSVPT HPTITKLRVL SRNQQLIRLD 120
  121 FEEGFEGVDP QPLHERINQA LSSIGALVLS DYAKGALASV QQMIQLARKA GVPVLIDPKG 180
  181 TDFERYRGAT LLTPNLSEFE AVVGKCKTEE EIVERGMKLI ADYELSALLV TRSEQGMSLL 240
  241 QPGKAPLHMP TQAQEVYDVT GAGDTVIGVL AATLAAGNSL EEACFFANAA AGVVVGKLGT 300
  301 STVSPIELEN AVRGRADTGF GV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	50.0
Match:	2fv7A
Description:	Crystal structure of human ribokinase
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [323-477]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTEEELKLAV AAARKRGEKV VMTNGVFDIL HAGHVSYLAN ARKLGDRLIV AVNSDASTKR  60
   61 LKGDSRPVNP LEQRMIVLGA LEAVDWVVSF EEDTPQRLIA GILPDLLVKG GDYKPEEIAG 120
  121 SKEVWANGGE VLVLNFEDGC STTNIIKKIQ QDKKG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	33.69897
Match:	1cozA
Description:	CTP:glycerol-3-phosphate cytidylyltransferase
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits