Bait Protein: | VAM3 |
Organism: | Saccharomyces cerevisiae |
Publication: | Hao Xu , Youngsoo Jun, James Thompson, John Yates and William Wickner (2010) HOPS Prevents the Disassembly of Trans-SNARE Complexes by Sec17p/Sec18p during Membrane Fusion [In Press] |
Comments: | Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). |
Raw Data: |
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FILTERED Run Results:
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Hit Protein | Protein Desc | Sequence Count | Spectrum Count | Sequence Coverage | NSAF | Mol. Wt. | |
[ |
VAM3 | Syntaxin-related protein required for vacuolar assembly; functions with Vam7p in vacuolar protein tr... | 21 | 179 | 43.1% | 0.0832 | 32498 |
[ |
GDI1 | GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissoc... | 42 | 173 | 68.1% | 0.0504 | 51206 |
[ |
PDA1 | E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarbo... | 18 | 47 | 35.5% | 0.0147 | 46343 |
[ |
URA2 | Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase), catalyzes t... | 29 | 46 | 17.7% | 0.00273 | 245123 |
[ |
FKS1 | Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic sub... | 19 | 44 | 13.6% | 0.00308 | 214849 |
[ |
PHO8 | Repressible alkaline phosphatase, a glycoprotein localized to the vacuole; regulated by levels of in... | 13 | 43 | 24.4% | 0.00999 | 63004 |
[ |
KAR2 | ATPase involved in protein import into the ER, also acts as a chaperone to mediate protein folding i... | 15 | 42 | 23.8% | 0.0081 | 74468 |
[ |
YPK9 | Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-t... | 17 | 42 | 15.1% | 0.00375 | 166749 |
[ |
GYP1 | Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, ... | 14 | 38 | 18.4% | 0.00784 | 73289 |
[ |
YCF1 | Vacuolar glutathione S-conjugate transporter of the ATP-binding cassette family, has a role in detox... | 16 | 30 | 12.7% | 0.0026 | 171120 |
[ |
PDB1 | E1 beta subunit of the pyruvate dehydrogenase (PDH) complex, which is an evolutionarily-conserved mu... | 7 | 28 | 26.2% | 0.0101 | 40054 |
[ |
PPN1 | Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer | 12 | 28 | 23.7% | 0.00546 | 78344 |
[ |
SEC17 | Peripheral membrane protein required for vesicular transport between ER and Golgi, the 'priming' ste... | 9 | 27 | 35.3% | 0.0122 | 32803 |
[ |
LAT1 | Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes... | 12 | 27 | 27.8% | 0.00736 | 51818 |
[ |
CDC19 | Pyruvate kinase, functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvat... | 9 | 24 | 27.0% | 0.00631 | 54545 |
[ |
SEC18 | ATPase required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuol... | 13 | 23 | 23.6% | 0.00399 | 84056 |
[ |
VTC3 | Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuol... | 12 | 23 | 19.0% | 0.00362 | 96553 |
[ |
FRA1 | Protein involved in negative regulation of transcription of iron regulon; forms an iron independent ... | 10 | 23 | 16.4% | 0.00404 | 84924 |
[ |
DAP2 | Dipeptidyl aminopeptidase, synthesized as a glycosylated precursor; localizes to the vacuolar membra... | 10 | 23 | 13.9% | 0.0037 | 93404 |
[ |
VTI1 | Protein involved in cis-Golgi membrane traffic; v-SNARE that interacts with two t-SNARES, Sed5p and ... | 5 | 21 | 32.3% | 0.0127 | 24668 |
[ |
FAA4 | Long chain fatty acyl-CoA synthetase, activates imported fatty acids with a preference for C12:0-C16... | 9 | 21 | 17.3% | 0.00398 | 77267 |
[ |
YDR089W | Protein of unknown function; deletion confers resistance to Nickel | 9 | 21 | 13.8% | 0.00318 | 98712 |
[ |
VTC4 | Vacuolar membrane polyphosphate polymerase; subunit of the vacuolar transporter chaperone (VTC) comp... | 11 | 20 | 13.5% | 0.00365 | 83155 |
[ |
GSC2 | Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore... | 10 | 20 | 7.0% | 0.00139 | 216988 |
[ |
SHM2 | Cytosolic serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrof... | 11 | 19 | 26.7% | 0.00533 | 52219 |
[ |
VPH1 | Subunit a of vacuolar-ATPase V0 domain, one of two isoforms (Vph1p and Stv1p); Vph1p is located in V... | 7 | 18 | 13.0% | 0.00282 | 95529 |
[ |
MNR2 | Vacuolar membrane protein required for magnesium homeostasis; putative magnesium transporter; has si... | 8 | 17 | 10.7% | 0.00231 | 109736 |
[ |
YBT1 | Transporter of the ATP-binding cassette (ABC) family involved in bile acid transport; similar to mam... | 13 | 17 | 9.5% | 0.00135 | 189161 |
[ |
VAM7 | Component of the vacuole SNARE complex involved in vacuolar morphogenesis; SNAP-25 homolog; function... | 5 | 16 | 18.7% | 0.00666 | 36711 |
[ |
HMG1 | One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate, whi... | 10 | 16 | 11.6% | 0.002 | 115625 |
[ |
VAM6 | Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by fa... | 9 | 16 | 11.3% | 0.00201 | 122881 |
[ |
ADE5,7 | Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole... | 6 | 16 | 10.0% | 0.00262 | 86068 |
[ |
CPS1 | Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions | 10 | 15 | 16.8% | 0.00342 | 64597 |
[ |
VAC8 | Phosphorylated and palmitoylated vacuolar membrane protein that interacts with Atg13p, required for ... | 6 | 15 | 14.0% | 0.00341 | 63208 |
[ |
YER138C | Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is proces... | 8 | 15 | 6.1% | 0.00112 | 198561 |
[ |
MNN1 | Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for add... | 7 | 14 | 10.9% | 0.00242 | 88529 |
[ |
PHO91 | Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90,... | 9 | 14 | 6.7% | 0.00206 | 99490 |
[ |
PDX1 | Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogena... | 7 | 13 | 23.7% | 0.00417 | 45362 |
[ |
VTC2 | Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuol... | 9 | 13 | 13.5% | 0.00206 | 95441 |
[ |
YME1 | Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible f... | 7 | 13 | 10.8% | 0.00229 | 81772 |
[ |
PHO84 | High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated... | 6 | 13 | 10.2% | 0.00291 | 64382 |
[ |
BPT1 | ABC type transmembrane transporter of MRP/CFTR family, found in vacuolar membrane, involved in the t... | 11 | 13 | 8.3% | 0.0011 | 176873 |
[ |
VAC7 | Integral vacuolar membrane protein involved in vacuole inheritance and morphology; activates Fab1p k... | 7 | 13 | 6.4% | 0.00147 | 128140 |
[ |
PMA1 | Plasma membrane H+-ATPase, pumps protons out of the cell; major regulator of cytoplasmic pH and plas... | 6 | 12 | 8.9% | 0.00172 | 99619 |
[ |
PEP3 | Component of CORVET tethering complex; vacuolar peripheral membrane protein that promotes vesicular ... | 7 | 12 | 8.6% | 0.00172 | 107398 |
[ |
SKG6 | Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell ... | 6 | 11 | 13.5% | 0.00197 | 81849 |
[ |
VPS41 | Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sort... | 5 | 11 | 7.2% | 0.00146 | 113412 |
[ |
PHO90 | Low-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthet... | 7 | 10 | 11.6% | 0.00149 | 97689 |
[ |
DBP2 | Essential ATP-dependent RNA helicase of the DEAD-box protein family, involved in nonsense-mediated m... | 5 | 10 | 11.0% | 0.00241 | 60999 |
[ |
ENA2 | P-type ATPase sodium pump, involved in Na+ efflux to allow salt tolerance; likely not involved in Li... | 7 | 10 | 9.2% | 0.0012 | 120317 |
[ |
ENA1 | P-type ATPase sodium pump, involved in Na+ and Li+ efflux to allow salt tolerance | 7 | 10 | 9.2% | 0.0012 | 120357 |
[ |
ENA5 | Protein with similarity to P-type ATPase sodium pumps, member of the Na+ efflux ATPase family | 7 | 10 | 9.2% | 0.0012 | 120296 |
[ |
RPP2B | Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction ... | 3 | 9 | 36.4% | 0.0108 | 11050 |
[ |
PSA1 | GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from ... | 4 | 9 | 18.0% | 0.00328 | 39566 |
[ |
YNL217W | Hypothetical protein | 5 | 9 | 14.1% | 0.00363 | 37151 |
[ |
NOP56 | Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that ... | 4 | 9 | 13.3% | 0.00235 | 56864 |
[ |
TCP1 | Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; inv... | 6 | 9 | 13.2% | 0.00212 | 60481 |
[ |
IVY1 | Phospholipid-binding protein that interacts with both Ypt7p and Vps33p, may partially counteract the... | 3 | 9 | 10.6% | 0.00261 | 49976 |
[ |
VNX1 | Low affinity vacuolar membrane localized monovalent cation/H+ antiporter; member of the calcium exch... | 5 | 9 | 7.5% | 0.0013 | 102499 |
[ |
VBA4 | Protein of unknown function with proposed role as a basic amino acid permease based on phylogeny; GF... | 4 | 9 | 7.3% | 0.00154 | 85683 |
[ |
PMC1 | Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions; prevents growth inhibition by activ... | 5 | 9 | 5.6% | 0.00101 | 130861 |
[ |
RPP2A | Ribosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction... | 3 | 8 | 36.8% | 0.00992 | 10746 |
[ |
CCC1 | Putative vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack ... | 5 | 8 | 19.9% | 0.00327 | 34250 |
[ |
YNL058C | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to th... | 3 | 8 | 18.0% | 0.00333 | 35046 |
[ |
SAC1 | Phosphatidylinositol phosphate (PtdInsP) phosphatase involved in hydrolysis of PtdIns[4]P; transmemb... | 6 | 8 | 14.6% | 0.00169 | 71125 |
[ |
TUB2 | Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymeriz... | 5 | 8 | 13.6% | 0.0023 | 50923 |
[ |
KRE6 | Protein required for beta-1,6 glucan biosynthesis; putative beta-glucan synthase; appears functional... | 6 | 8 | 12.5% | 0.00146 | 80123 |
[ |
HSP60 | Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides... | 5 | 8 | 12.4% | 0.00184 | 60752 |
[ |
VMA6 | Subunit d of the five-subunit V0 integral membrane domain of vacuolar H+-ATPase (V-ATPase), an elect... | 3 | 8 | 11.9% | 0.00305 | 39791 |
[ |
PDI1 | Protein disulfide isomerase, multifunctional protein resident in the endoplasmic reticulum lumen, es... | 3 | 8 | 9.0% | 0.00201 | 58227 |
[ |
TFP1 | Subunit A of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase; protein prec... | 6 | 8 | 8.2% | 9.82E-4 | 118637 |
[ |
FET5 | Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron tra... | 4 | 8 | 7.1% | 0.00169 | 70880 |
[ |
TEF1, TEF2 | Translational elongation factor EF-1 alpha; also encoded by TEF2; functions in the binding reaction ... | 3 | 8 | 6.8% | 0.0023 | 50033 |
[ |
ZRC1 | Vacuolar membrane zinc transporter, transports zinc from the cytosol into the vacuole for storage; a... | 2 | 8 | 6.3% | 0.00238 | 48345 |
[ |
PEP5 | Component of CORVET tethering complex; peripheral vacuolar membrane protein required for protein tra... | 4 | 8 | 4.2% | 0.00102 | 117477 |
[ |
PIL1 | Primary component of eisosomes, which are large immobile cell cortex structures associated with endo... | 5 | 7 | 22.4% | 0.00271 | 38349 |
[ |
YNR061C | Putative protein of unknown function | 3 | 7 | 19.6% | 0.0042 | 24317 |
[ |
LPD1 | Dihydrolipoamide dehydrogenase, the lipoamide dehydrogenase component (E3) of the pyruvate dehydroge... | 6 | 7 | 15.4% | 0.00184 | 54010 |
[ |
SMF3 | Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by... | 5 | 7 | 12.5% | 0.00195 | 51775 |
[ |
TUB1 | Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form... | 3 | 7 | 10.1% | 0.00206 | 49800 |
[ |
CCT8 | Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of... | 4 | 7 | 9.7% | 0.00162 | 61662 |
[ |
RMD8 | Cytosolic protein required for sporulation | 3 | 7 | 6.6% | 0.00139 | 75914 |
[ |
CHS2 | Chitin synthase II; catalyzes transfer of N-acetylglucosamine (GlcNAc) to chitin upon activation of ... | 4 | 7 | 6.1% | 9.56E-4 | 109882 |
[ |
SNA3 | Integral membrane protein localized to vacuolar intralumenal vesicles, computational analysis of lar... | 2 | 6 | 31.6% | 0.00593 | 15199 |
[ |
TUF1 | Mitochondrial translation elongation factor Tu; comprises both GTPase and guanine nucleotide exchang... | 4 | 6 | 14.4% | 0.0018 | 47972 |
[ |
NYV1 | v-SNARE component of the vacuolar SNARE complex involved in vesicle fusion; inhibits ATP-dependent C... | 3 | 6 | 14.2% | 0.00312 | 28964 |
[ |
RPP0 | Conserved ribosomal protein P0 similar to rat P0, human P0, and E. coli L10e; shown to be phosphoryl... | 3 | 6 | 12.5% | 0.00253 | 33717 |
[ |
NPL3 | RNA-binding protein that promotes elongation, regulates termination, and carries poly(A) mRNA from n... | 3 | 6 | 11.8% | 0.00191 | 45407 |
[ |
HXT3 | Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low ... | 4 | 6 | 10.1% | 0.00139 | 62558 |
[ |
YJL132W | Putative protein of unknown function; localizes to the membrane fraction; possible Zap1p-regulated t... | 5 | 6 | 9.1% | 0.00105 | 84466 |
[ |
GPA1 | GTP-binding alpha subunit of the heterotrimeric G protein that couples to pheromone receptors; negat... | 3 | 6 | 9.1% | 0.00167 | 54076 |
[ |
SEC63 | Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/Bi... | 5 | 6 | 8.0% | 0.00119 | 75345 |
[ |
YCK3 | Palmitoylated, vacuolar membrane-localized casein kinase I isoform; negatively regulates vacuole fus... | 3 | 6 | 7.8% | 0.00151 | 60261 |
[ |
YGR125W | Putative protein of unknown function; deletion mutant has decreased rapamycin resistance but normal ... | 4 | 6 | 5.2% | 7.61E-4 | 116971 |
[ |
KOG1 | Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or To... | 4 | 6 | 4.1% | 5.07E-4 | 177608 |
[ |
PDR5 | Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter actively regulated by ... | 4 | 6 | 3.8% | 5.22E-4 | 170437 |
[ |
PEP12 | Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus... | 4 | 5 | 18.1% | 0.00228 | 33006 |
[ |
KTR6 | Probable mannosylphosphate transferase involved in the synthesis of core oligosaccharides in protein... | 4 | 5 | 15.5% | 0.00147 | 52128 |
[ |
NVJ1 | Nuclear envelope protein, anchored to the nuclear inner membrane, that interacts with the vacuolar m... | 3 | 5 | 15.3% | 0.00205 | 36421 |
[ |
RHR2 | Constitutively expressed isoform of DL-glycerol-3-phosphatase; involved in glycerol biosynthesis, in... | 3 | 5 | 15.1% | 0.00243 | 30439 |
[ |
HMX1 | ER localized, heme-binding peroxidase involved in the degradation of heme; does not exhibit heme oxy... | 2 | 5 | 11.0% | 0.00207 | 37179 |
[ |
VAN1 | Component of the mannan polymerase I, which contains Van1p and Mnn9p and is involved in the first st... | 3 | 5 | 10.3% | 0.00123 | 61092 |
[ |
NOP1 | Nucleolar protein, component of the small subunit processome complex, which is required for processi... | 3 | 5 | 10.1% | 0.00201 | 34465 |
[ |
VMA2 | Subunit B of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), a... | 4 | 5 | 9.5% | 0.00127 | 57749 |
[ |
LCB4 | Sphingoid long-chain base kinase, responsible for synthesis of long-chain base phosphates, which fun... | 4 | 5 | 9.3% | 0.00105 | 69639 |
[ |
MAM3 | Protein required for normal mitochondrial morphology, has similarity to hemolysins | 4 | 5 | 9.2% | 9.31E-4 | 77712 |
[ |
EFT2, EFT1 | Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein s... | 5 | 5 | 8.3% | 7.81E-4 | 93289 |
[ |
SYG1 | Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G... | 4 | 5 | 7.5% | 7.29E-4 | 104217 |
[ |
CHS1 | Chitin synthase I, requires activation from zymogenic form in order to catalyze the transfer of N-ac... | 4 | 5 | 5.0% | 5.81E-4 | 129919 |
[ |
GOS1 | v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28 | 3 | 4 | 22.9% | 0.00236 | 25395 |
[ |
RNA1 | GTPase activating protein (GAP) for Gsp1p, involved in nuclear transport | 4 | 4 | 14.5% | 0.00129 | 45816 |
[ |
TLG1 | Essential t-SNARE that forms a complex with Tlg2p and Vti1p and mediates fusion of endosome-derived ... | 2 | 4 | 12.9% | 0.00235 | 25817 |
[ |
MNN11 | Subunit of a Golgi mannosyltransferase complex that also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, a... | 4 | 4 | 11.4% | 0.00125 | 47801 |
[ |
PRM5 | Pheromone-regulated protein, predicted to have 1 transmembrane segment; induced during cell integrit... | 3 | 4 | 10.7% | 0.00165 | 34651 |
[ |
PDC1 | Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermentation, decarboxylates... | 3 | 4 | 9.4% | 9.34E-4 | 61495 |
[ |
YBR287W | Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; YBR... | 3 | 4 | 9.4% | 0.00123 | 47506 |
[ |
NOP58 | Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the ... | 3 | 4 | 9.2% | 0.00103 | 56956 |
[ |
YDL180W | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to th... | 3 | 4 | 7.1% | 9.61E-4 | 62288 |
[ |
EPS1 | ER protein with chaperone and co-chaperone activity, involved in retention of resident ER proteins; ... | 3 | 4 | 7.0% | 7.5E-4 | 81219 |
[ |
KTR1 | Alpha-1,2-mannosyltransferase involved in O- and N-linked protein glycosylation; type II membrane pr... | 2 | 4 | 6.9% | 0.00134 | 46022 |
[ |
ERV46 | Protein localized to COPII-coated vesicles, forms a complex with Erv41p; involved in the membrane fu... | 2 | 4 | 6.0% | 0.00127 | 46235 |
[ |
KRE2 | Alpha1,2-mannosyltransferase of the Golgi involved in protein mannosylation | 2 | 4 | 5.7% | 0.00119 | 51387 |
[ |
RSP5 | E3 ubiquitin ligase of the NEDD4 family; involved in regulating many cellular processes, including M... | 4 | 4 | 5.4% | 6.5E-4 | 91816 |
[ |
VPS33 | ATP-binding protein that is a subunit of the HOPS complex and of the CORVET tethering complex; essen... | 3 | 4 | 5.2% | 7.61E-4 | 79271 |
[ |
FPS1 | Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glyce... | 2 | 4 | 5.2% | 7.86E-4 | 73877 |
[ |
DED1 | ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, required for translation initiation of all ye... | 2 | 4 | 4.5% | 8.71E-4 | 65553 |
[ |
YLR241W | Putative protein of unknown function, may be involved in detoxification | 3 | 4 | 4.1% | 6.72E-4 | 89344 |
[ |
TRE2 | Protein that functions with Tre1p to regulate ubiquitylation and vacuolar degradation of the metal t... | 2 | 4 | 3.0% | 6.5E-4 | 91995 |
[ |
DIP5 | Dicarboxylic amino acid permease, mediates high-affinity and high-capacity transport of L-glutamate ... | 3 | 4 | 3.0% | 8.65E-4 | 68098 |
[ |
YDR338C | Putative protein of unknown function | 2 | 4 | 2.9% | 7.57E-4 | 77846 |
[ |
PEP1 | Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golg... | 3 | 4 | 2.5% | 3.33E-4 | 177777 |
[ |
DID4 | Class E Vps protein of the ESCRT-III complex, required for sorting of integral membrane proteins int... | 3 | 3 | 13.8% | 0.0017 | 26291 |
[ |
YPT7 | Rab family GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vac... | 2 | 3 | 13.5% | 0.0019 | 23043 |
[ |
ROT1 | Molecular chaperone involved in protein folding in the ER; mutation causes defects in cell wall synt... | 2 | 3 | 12.1% | 0.00154 | 28908 |
[ |
SNF7 | One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involv... | 2 | 3 | 11.7% | 0.00164 | 26987 |
[ |
CCT7 | Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of... | 3 | 3 | 8.4% | 7.17E-4 | 59736 |
[ |
YOL019W | Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell pe... | 3 | 3 | 8.2% | 7.16E-4 | 60901 |
[ |
SCJ1 | One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates wit... | 2 | 3 | 8.0% | 0.00105 | 41543 |
[ |
SAM1 | S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom ... | 2 | 3 | 6.8% | 0.00103 | 41818 |
[ |
CCT4 | Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of... | 2 | 3 | 5.9% | 7.47E-4 | 57604 |
[ |
OLE1 | Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal dis... | 2 | 3 | 5.7% | 7.73E-4 | 58403 |
[ |
VPS16 | Subunit of the vacuole fusion and protein sorting HOPS complex and the CORVET tethering complex; par... | 3 | 3 | 5.3% | 4.94E-4 | 92741 |
[ |
PFK1 | Alpha subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaer... | 3 | 3 | 4.7% | 4.0E-4 | 107970 |
[ |
TGL4 | Multifunctional triacylglycerol lipase, steryl ester hydrolase, and Ca2+-independent phospholipase A... | 3 | 3 | 4.6% | 4.33E-4 | 102716 |
[ |
LYP1 | Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of c... | 2 | 3 | 4.4% | 6.45E-4 | 68090 |
[ |
SWH1 | Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats; localizes to the G... | 3 | 3 | 4.3% | 3.32E-4 | 135070 |
[ |
YVC1 | Vacuolar cation channel, mediates release of Ca(2+) from the vacuole in response to hyperosmotic sho... | 2 | 3 | 3.7% | 5.84E-4 | 77953 |
[ |
MHP1 | Microtubule-associated protein involved in assembly and stabilization of microtubules; overproductio... | 3 | 3 | 3.6% | 2.82E-4 | 155207 |
[ |
SEY1 | GTPase with a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; poss... | 2 | 3 | 3.6% | 5.08E-4 | 89433 |
[ |
HMG2 | One of two isozymes of HMG-CoA reductase that convert HMG-CoA to mevalonate, a rate-limiting step in... | 2 | 3 | 2.8% | 3.77E-4 | 115692 |
[ |
IES5 | Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions | 2 | 2 | 21.6% | 0.0021 | 14312 |
[ |
TSA1 | Thioredoxin peroxidase, acts as both a ribosome-associated and free cytoplasmic antioxidant; self-as... | 2 | 2 | 14.8% | 0.00134 | 21590 |
[ |
GSF2 | ER localized integral membrane protein that may promote secretion of certain hexose transporters, in... | 2 | 2 | 9.4% | 6.52E-4 | 45870 |
[ |
PGK1 | 3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phospha... | 2 | 2 | 7.7% | 6.32E-4 | 44738 |
[ |
ECM14 | Putative metalloprotease with similarity to the zinc carboxypeptidase family, required for normal ce... | 2 | 2 | 6.7% | 6.11E-4 | 49829 |
[ |
PGC1 | Phosphatidyl Glycerol phospholipase C; regulates the phosphatidylglycerol (PG) content via a phospho... | 2 | 2 | 6.5% | 8.19E-4 | 37070 |
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PTR2 | Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein... | 2 | 2 | 6.3% | 4.37E-4 | 68044 |
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RMD1 | Cytoplasmic protein required for sporulation | 2 | 2 | 6.0% | 6.11E-4 | 49932 |
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YDL199C | Putative transporter, member of the sugar porter family | 2 | 2 | 5.5% | 3.83E-4 | 77501 |
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VTC1 | Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuol... | 2 | 2 | 5.4% | 0.00204 | 14371 |
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EAR1 | Specificity factor required for Rsp5p-dependent ubiquitination and sorting of specific cargo protein... | 2 | 2 | 5.3% | 4.78E-4 | 62532 |
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ERG1 | Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential r... | 2 | 2 | 5.2% | 5.3E-4 | 55126 |
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DBP3 | Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis | 2 | 2 | 5.0% | 5.03E-4 | 58827 |
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SKT5 | Activator of Chs3p (chitin synthase III), recruits Chs3p to the bud neck via interaction with Bni4p;... | 2 | 2 | 4.9% | 3.78E-4 | 77066 |
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ERG11 | Lanosterol 14-alpha-demethylase, catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimeth... | 2 | 2 | 4.9% | 4.96E-4 | 60720 |
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SSH4 | Specificity factor required for Rsp5p-dependent ubiquitination and sorting of cargo proteins at the ... | 2 | 2 | 4.7% | 4.54E-4 | 65061 |
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NOG1 | Putative GTPase that associates with free 60S ribosomal subunits in the nucleolus and is required fo... | 2 | 2 | 4.6% | 4.06E-4 | 74410 |
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MNT2 | Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans | 2 | 2 | 4.5% | 4.71E-4 | 64853 |
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GRS1 | Cytoplasmic and mitochondrial glycyl-tRNA synthase that ligates glycine to the cognate anticodon bea... | 2 | 2 | 4.2% | 3.94E-4 | 75411 |
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FRE1 | Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to u... | 2 | 2 | 3.5% | 3.83E-4 | 78854 |
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CHS3 | Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for ... | 2 | 2 | 3.4% | 2.26E-4 | 131601 |
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IRC8 | Bud tip localized protein of unknown function; mRNA is targeted to the bud by a She2p dependent tran... | 2 | 2 | 3.4% | 3.2E-4 | 91256 |
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KRE33 | Essential protein, required for biogenesis of the small ribosomal subunit; heterozygous mutant shows... | 2 | 2 | 3.1% | 2.49E-4 | 119347 |
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YBR235W | Putative ion transporter, similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family; Y... | 2 | 2 | 2.8% | 2.35E-4 | 123998 |
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RPN1 | Non-ATPase base subunit of the 19S regulatory particle of the 26S proteasome; may participate in the... | 2 | 2 | 2.8% | 2.65E-4 | 109492 |
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YBL104C | Putative protein of unknown function, promoter contains multiple GCN4 binding sites | 2 | 2 | 2.5% | 2.53E-4 | 117636 |
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VTH2 | Putative membrane glycoprotein with strong similarity to Vth1p and Pep1p/Vps10p, may be involved in ... | 2 | 2 | 1.9% | 1.7E-4 | 174401 |
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VTH1 | Putative membrane glycoprotein with strong similarity to Vth2p and Pep1p/Vps10p, may be involved in ... | 2 | 2 | 1.9% | 1.7E-4 | 174427 |