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Any process that prevents the activation of anaphase-promoting complex activity regulating the mitotic cell cycle. Any process that stops, prevents or reduces the frequency, rate or extent of the mitotic metaphase to anaphase transition. Any process that decreases the rate frequency or extent of anaphase-promoting complex activity regulating the mitotic cell cycle. Any process that stops, prevents or reduces the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin ligase activity that contributes to the mitotic cell cycle. The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: inhibition of mitotic anaphase-promoting complex activity
Acc: GO:0060565
Aspect: Biological Process
Desc: Any process that prevents the activation of anaphase-promoting complex activity regulating the mitotic cell cycle.
Synonyms:
  • inhibition of APC activity during mitotic cell cycle
  • inhibition of cyclosome activity during mitotic cell cycle
  • inhibition of APC/C activity during mitotic cell cycle
Proteins in PDR annotated with:
   This term: 2 [Search]
   Term or descendants: 2 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0060565 - inhibition of mitotic anaphase-promoting complex activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle