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Interacting selectively and non-covalently with DNA of a specific structure or configuration e.g. triplex DNA binding or bent DNA binding. Interacting selectively and non-covalently with G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad. The stacking of guanine tetrads results in G-quadruplex DNA structures. G-quadruplex DNA can form under physiological conditions from some G-rich sequences, such as those found in telomeres, immunoglobulin switch regions, gene promoters, fragile X repeats, and the dimerization domain in the human immunodeficiency virus (HIV) genome. Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid).

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: G-quadruplex DNA binding
Acc: GO:0051880
Aspect: Molecular Function
Desc: Interacting selectively and non-covalently with G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad. The stacking of guanine tetrads results in G-quadruplex DNA structures. G-quadruplex DNA can form under physiological conditions from some G-rich sequences, such as those found in telomeres, immunoglobulin switch regions, gene promoters, fragile X repeats, and the dimerization domain in the human immunodeficiency virus (HIV) genome.
Synonyms:
  • G-quartet DNA binding
  • G quadruplex DNA binding
  • G quartet binding
  • G-DNA binding
  • quadruplex DNA binding
  • tetraplex DNA binding
  • G-quartet binding
  • G quartet DNA binding
Proteins in PDR annotated with:
   This term: 6 [Search]
   Term or descendants: 6 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0051880 - G-quadruplex DNA binding (interactive image map)
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