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The series of successive proteolytic cleavages of the Notch protein, which result in an active form of the receptor. The second process in a series of specific posttranslational modifications to the CAAX box region of CAAX box proteins, in which the last three amino acids of the protein (AAX) are removed by proteolysis. Removal of the initiating methionine or formylmethionine residue from a protein that contributes to protein maturation, the attainment of the full functional capacity of a protein. The proteolytic cleavages to the Notch protein that occur prior to ligand binding. A primary cleavage event within the extracellular domain whilst the Notch protein in still in the secretory pathway, leads to the transportation of a processed heterodimer to the cell surface. The hydrolysis of a peptide bond or bonds within a protein as part of protein maturation, the process leading to the attainment of the full functional capacity of a protein. Any process leading to the attainment of the full functional capacity of a protein. Any process that modulates the rate, frequency or extent of protein maturation by peptide bond cleavage. Any process that increases the rate, frequency or extent of protein maturation by peptide bond cleavage. The proteolytic cleavages to the Notch protein that occur as a result of ligand binding. Ligand binding at the cell surface exposes an otherwise inaccessible cleavage site in the extracellular portion of Notch, which when cleaved releases a membrane-tethered form of the Notch intracellular domain. Subsequent cleavage within the transmembrane domain then leads to the release of the soluble Notch intracellular domain (NICD). The generation of a mature peptide hormone by posttranslational processing of a prohormone. Any protein maturation process achieved by the cleavage of peptide bonds. The proteolysis of epidermal growth factor after its internalization via binding to its receptor. Any process activating plasma proteins by proteolysis as part of an acute inflammatory response. The proteolytic release of a transcriptionally active sterol regulatory element binding protein (SREBP) from intracellular membranes, freeing it to move to the nucleus and upregulate transcription of target genes, in response to altered levels of one or more lipids. Any process that decreases the rate, frequency or extent of protein maturation by peptide bond cleavage. The proteolytic processing of an inactive enzyme to an active form. The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: protein maturation by peptide bond cleavage
Acc: GO:0051605
Aspect: Biological Process
Desc: The hydrolysis of a peptide bond or bonds within a protein as part of protein maturation, the process leading to the attainment of the full functional capacity of a protein.
Synonyms:
  • protein maturation by proteolysis
  • protein maturation by peptide bond hydrolysis
  • peptidolysis during protein maturation
Proteins in PDR annotated with:
   This term: 45 [Search]
   Term or descendants: 276 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0051605 - protein maturation by peptide bond cleavage (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle