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Any process that stops or reduces the rate of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. The process by which one or more ubiquitin moieties are added to a protein. Any process that modulates the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. Any process that modulates the frequency, rate or extent of ubiquitin ligase activity, the catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin ligase activity, the catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. Any process that modulates the frequency, rate or extent of the addition of ubiquitin moieties to a protein. Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin ligase activity during the meiotic cell cycle. Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin ligase activity that contributes to the mitotic cell cycle. Any process that stops, prevents or reduces the frequency, rate or extent of the addition of ubiquitin moieties to a protein. Any process that stops or reduces the activity of an enzyme. Any process that stops, prevents or reduces the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of ubiquitin-protein ligase activity
Acc: GO:0051444
Aspect: Biological Process
Desc: Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin ligase activity, the catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
Synonyms:
  • anaphase-promoting complex inhibition
  • down-regulation of ubiquitin ligase activity
  • downregulation of ubiquitin ligase activity
  • negative regulation of ubiquitin ligase activity
  • ubiquitin ligase inhibitor
  • APC inhibitor
  • anaphase promoting complex inhibitor
  • APC inhibition
  • inhibition of ubiquitin ligase activity
  • SCF complex inhibitor
  • anaphase-promoting complex inhibitor
  • anaphase promoting complex inhibition
  • down regulation of ubiquitin ligase activity
Proteins in PDR annotated with:
   This term: 5 [Search]
   Term or descendants: 88 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0051444 - negative regulation of ubiquitin-protein ligase activity (interactive image map)
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