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Any process that modulates the frequency, rate or extent of isotype switching to IgG isotypes. The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. The process by which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of an immune response. The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus. The switching of activated B cells from IgM biosynthesis to biosynthesis of an IgG isotype, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and one of the IgG constant region gene segments in the immunoglobulin heavy chain locus. Any process that stops, prevents or reduces the frequency, rate or extent of isotype switching to IgG isotypes. Any process that activates or increases the frequency, rate or extent of isotype switching to IgG isotypes.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: isotype switching to IgG isotypes
Acc: GO:0048291
Aspect: Biological Process
Desc: The switching of activated B cells from IgM biosynthesis to biosynthesis of an IgG isotype, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and one of the IgG constant region gene segments in the immunoglobulin heavy chain locus.
Synonyms:
  • isotype switch recombination to IgG isotypes
  • class switching to IgG isotypes
Proteins in PDR annotated with:
   This term: 1 [Search]
   Term or descendants: 23 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0048291 - isotype switching to IgG isotypes (interactive image map)
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