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The process by which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class I protein complex. Class I here refers to classical class I molecules. The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. The binding of a peptide to the antigen binding groove of an MHC protein complex. The process by which an antigen-presenting cell expresses peptide antigen in association with an MHC class Ib protein complex on its cell surface. The peptide antigen may originate from an endogenous or exogenous protein. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E family. The process by which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein. The hydrolysis of a peptide bond or bonds within a protein contributing to antigen processing and presentation. The process by which an antigen-presenting cell expresses peptide antigen in association with an MHC protein complex on its cell surface, including proteolysis and transport steps for the peptide antigen both prior to and following assembly with the MHC protein complex. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein. Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen. Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen. Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen. Any process involved in maintaining the structure and integrity of a peptide antigen and preventing it from being degraded. The directed movement of a peptide antigen into, out of, within or between cells by means of some external agent such as a transporter or pore. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein. The process by which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. The process by which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: antigen processing and presentation of peptide antigen
Acc: GO:0048002
Aspect: Biological Process
Desc: The process by which an antigen-presenting cell expresses peptide antigen in association with an MHC protein complex on its cell surface, including proteolysis and transport steps for the peptide antigen both prior to and following assembly with the MHC protein complex. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein.
Synonyms:
  • peptide antigen processing and presentation
  • antigen presentation, peptide antigen
Proteins in PDR annotated with:
   This term: 22 [Search]
   Term or descendants: 195 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0048002 - antigen processing and presentation of peptide antigen (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle