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Any process that stops, prevents or reduces the frequency, rate or extent of a signaling pathway. Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. Any process that modulates the frequency, rate or extent of a signaling pathway. Any process that stops, prevents or reduces the frequency, rate or extent of the Notch signaling pathway. The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell. The series of molecular events whereby information is sent from one location to another within a living organism or between living organisms. Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. Any process that modulates the frequency, rate or extent of the Notch signaling pathway. Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of Notch signaling pathway
Acc: GO:0045746
Aspect: Biological Process
Desc: Any process that stops, prevents or reduces the frequency, rate or extent of the Notch signaling pathway.
Synonyms:
  • inhibition of Notch signaling pathway
  • negative regulation of Notch signalling pathway
  • negative regulation of N signalling pathway
  • down-regulation of Notch signaling pathway
  • downregulation of Notch signaling pathway
  • down regulation of Notch signaling pathway
  • negative regulation of N signaling pathway
Proteins in PDR annotated with:
   This term: 37 [Search]
   Term or descendants: 37 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0045746 - negative regulation of Notch signaling pathway (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle