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The process whereby a relatively unspecialized thymocyte acquires specialized features of a T-helper cell. An immune response which is associated with resistance to extracellular organisms such as helminths and pathological conditions such as allergy, which is typically orchestrated by the production of particular cytokines by T-helper 2 cells, most notably IL-4, IL-5, IL-10, and IL-13, resulting in enhanced production of certain antibody isotypes and other effects. An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies). An example of this is the adaptive immune response found in Mus musculus. Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 2 cell differentiation. The process whereby a relatively unspecialized T cell acquires specialized features of a Th2 cell. Any process that modulates the frequency, rate or extent of T-helper 2 cell differentiation. The process whereby an antigenically nave CD4-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell during an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells. The process whereby a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 2 cell, a CD4-positive, alpha-beta T cell specialized to promote immunological processes often associated with resistance to extracellular organisms such as helminths, enhanced production of particular antibody isotypes, and pathological conditions such as allergy. Any process that activates or increases the frequency, rate or extent of T-helper 2 cell differentiation.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: T-helper 2 cell differentiation
Acc: GO:0045064
Aspect: Biological Process
Desc: The process whereby a relatively unspecialized T cell acquires specialized features of a Th2 cell.
Proteins in PDR annotated with:
   This term: 1 [Search]
   Term or descendants: 11 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0045064 - T-helper 2 cell differentiation (interactive image map)
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