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A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. The insertion of integral proteins into the endoplasmic reticulum membrane. Stop-transfer membrane-anchor sequences become an ER membrane spanning helix. The insertion of integral proteins into the endoplasmic reticulum membrane. Signal anchor sequences function as both ER signal sequences and membrane anchor sequences. The insertion of integral proteins into the endoplasmic reticulum membrane. Proteins become anchored to the phospholipid bilayer by a covalently attached glycosylphosphatidylinositol (GPI) molecule. The process by which a protein is incorporated into a biological membrane. Any process by which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a membrane. Any process by which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell. The process by which a protein is incorporated into an endoplasmic reticulum (ER) membrane. It depends on specific topogenic sequences of amino acids that ensure that a protein acquires the proper orientation during its insertion into the ER membrane. A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum. A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. The insertion of integral proteins into the endoplasmic reticulum membrane. N-terminal cleaved signal sequences direct polypeptides to the ER.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: protein insertion into ER membrane
Acc: GO:0045048
Aspect: Biological Process
Desc: The process by which a protein is incorporated into an endoplasmic reticulum (ER) membrane. It depends on specific topogenic sequences of amino acids that ensure that a protein acquires the proper orientation during its insertion into the ER membrane.
Synonyms:
  • protein-endoplasmic reticulum insertion
  • integral ER membrane protein positioning
  • positioning of protein in ER membrane
  • integral ER membrane protein localization
  • protein-ER insertion
  • protein insertion into endoplasmic reticulum membrane
  • localization of protein in ER membrane
Proteins in PDR annotated with:
   This term: 6 [Search]
   Term or descendants: 6 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0045048 - protein insertion into ER membrane (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle