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The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells. The process whereby a signal is secreted or discharged into the extracellular medium from a cellular source. Any process that modulates the frequency, rate or extent of corticotropin-releasing hormone secretion. The regulated release of corticotropin-releasing hormone (CRH), a polypeptide hormone involved in the stress response. CRH is produced by the hypothalamus and stimulates corticotropic cells of the anterior lobe of the pituitary to produce adrenocorticotrophic hormone (ACTH) and other biologically active substances e.g. 2-endorphin, release of CRH is affected by serum levels of cortisol, by stress and by the sleep/wake cycle. Any process that activates or increases the frequency, rate or extent of the regulated release of corticotropin-releasing hormone from a cell or group of cells. The controlled release of a substance by a cell. Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of corticotropin-releasing hormone from a cell or group of cells. The directed movement of hormones into, out of, within or between cells by means of some external agent such as a transporter or pore.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: corticotropin-releasing hormone secretion
Acc: GO:0043396
Aspect: Biological Process
Desc: The regulated release of corticotropin-releasing hormone (CRH), a polypeptide hormone involved in the stress response. CRH is produced by the hypothalamus and stimulates corticotropic cells of the anterior lobe of the pituitary to produce adrenocorticotrophic hormone (ACTH) and other biologically active substances e.g. 2-endorphin, release of CRH is affected by serum levels of cortisol, by stress and by the sleep/wake cycle.
Synonyms:
  • CRF secretion
  • CRH secretion
  • corticotropin-releasing factor secretion
Proteins in PDR annotated with:
   This term: 0
   Term or descendants: 1 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0043396 - corticotropin-releasing hormone secretion (interactive image map)

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Created and Maintained by: Michael Riffle