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The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. The directed movement of substances from late endosomes to the vacuole. In yeast, after transport to the prevacuolar compartment, endocytic content is delivered to the late endosome and on to the vacuole. This pathway is analogous to endosome to lysosome transport. The directed movement of substances into, out of or within a vacuole. The directed movement of substances from endosomes to vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the vacuole. The process of directing proteins towards the vacuole, usually using signals contained within the protein. The directed movement of substances from endosomes to lysosomes or vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the target compartment. The process of targeting specific proteins to particular membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif. The process of directing proteins towards the vacuole using signals contained within the protein, occurring during protein catabolism via the multivesicular body (MVB) pathway. The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: protein targeting to vacuole during ubiquitin-dependent protein catabolic process via the MVB pathway
Acc: GO:0043328
Aspect: Biological Process
Desc: The process of directing proteins towards the vacuole using signals contained within the protein, occurring during protein catabolism via the multivesicular body (MVB) pathway.
Synonyms:
  • protein vacuolar targeting during ubiquitin-dependent protein catabolism via the MVB pathway
  • protein targeting to vacuole during ubiquitin-dependent protein degradation via the MVB pathway
  • protein targeting to vacuole during ubiquitin-dependent protein breakdown via the MVB pathway
  • protein-vacuolar targeting during ubiquitin-dependent protein degradation via the MVB pathway
  • protein-vacuole targeting during ubiquitin-dependent protein catabolic process via the MVB pathway
  • protein-vacuole targeting during ubiquitin-dependent protein catabolism via the MVB pathway
  • protein vacuolar targeting during ubiquitin-dependent protein catabolic process via the MVB pathway
  • protein-vacuolar targeting during ubiquitin-dependent protein breakdown via the MVB pathway
Proteins in PDR annotated with:
   This term: 21 [Search]
   Term or descendants: 21 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0043328 - protein targeting to vacuole during ubiquitin-dependent protein catabolic process via the MVB pathway (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle