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Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. A heterotrimeric H4/H2A histone acetyltransferase complex with a substrate preference of chromatin over free histones. It contains a subset of the proteins found in the larger NuA4 histone acetyltransferase complex; for example, the S. cerevisiae complex contains Esa1p, Yng2p, and Epl1p. A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60). A protein complex that possesses histone acetyltransferase activity. A multisubunit complex that catalyzes the acetylation of histones H4 and H2A. Any constituent part of the nucleoplasm, that part of the nuclear content other than the chromosomes or the nucleolus.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: H4/H2A histone acetyltransferase complex
Acc: GO:0043189
Aspect: Cellular Component
Desc: A multisubunit complex that catalyzes the acetylation of histones H4 and H2A.
Synonyms:
  • H4/H2A HAT complex
Proteins in PDR annotated with:
   This term: 12 [Search]
   Term or descendants: 71 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0043189 - H4/H2A histone acetyltransferase complex (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle