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Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. Catalysis of the reaction: (R)-mevalonate + CoA + 2 NAD+ = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+. Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: hydroxymethylglutaryl-CoA reductase activity
Acc: GO:0042282
Aspect: Molecular Function
Desc: Catalysis of the reaction: (R)-mevalonate + CoA + 2 NAD+ = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+.
Synonyms:
  • 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity
  • 3-hydroxy-3-methylglutaryl coenzyme A reductase activity
  • HMG-CoA reductase activity
  • beta-hydroxy-beta-methylglutaryl coenzyme A reductase activity
  • hydroxymethylglutaryl coenzyme A reductase activity
  • beta-hydroxy-beta-methylglutaryl CoA-reductase activity
  • (R)-mevalonate:NAD+ oxidoreductase (CoA-acylating)
  • hydroxymethylglutaryl-CoA reductase (NADH) activity
Proteins in PDR annotated with:
   This term: 4 [Search]
   Term or descendants: 4 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0042282 - hydroxymethylglutaryl-CoA reductase activity (interactive image map)
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