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An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory). An immune response which is associated with resistance to extracellular organisms such as helminths and pathological conditions such as allergy, which is typically orchestrated by the production of particular cytokines by T-helper 2 cells, most notably IL-4, IL-5, IL-10, and IL-13, resulting in enhanced production of certain antibody isotypes and other effects. Any process that stops, prevents, or reduces the frequency, rate, or extent of a T-helper 2 type immune response. An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies). An example of this is the adaptive immune response found in Mus musculus. The process whereby a relatively unspecialized T cell acquires specialized features of a Th2 cell. Any process that modulates the frequency, rate, or extent of a T-helper 2 type immune response. Any process that activates or increases the frequency, rate, or extent of a T-helper 2 type immune response.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: T-helper 2 type immune response
Acc: GO:0042092
Aspect: Biological Process
Desc: An immune response which is associated with resistance to extracellular organisms such as helminths and pathological conditions such as allergy, which is typically orchestrated by the production of particular cytokines by T-helper 2 cells, most notably IL-4, IL-5, IL-10, and IL-13, resulting in enhanced production of certain antibody isotypes and other effects.
Synonyms:
  • Th2 immune response
Proteins in PDR annotated with:
   This term: 1 [Search]
   Term or descendants: 19 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0042092 - T-helper 2 type immune response (interactive image map)
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