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Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. Any process by which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner. The nucleic acid metabolic process by which the phosphodiester bonds between nucleotides are cleaved by hydrolysis. Downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: mRNA cleavage or translational repression. Any process of posttranscriptional gene inactivation (silencing) mediated by small RNA molecules that may trigger mRNA degradation or negatively regulate translation. The process by which microRNAs (miRNAs) direct the cleavage of target mRNAs. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA will typically direct cleavage by base pairing with near-perfect complementarity to the target mRNA. Many plant miRNAs downregulate gene expression through this mechanism.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: mRNA cleavage involved in gene silencing by miRNA
Acc: GO:0035279
Aspect: Biological Process
Desc: The process by which microRNAs (miRNAs) direct the cleavage of target mRNAs. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA will typically direct cleavage by base pairing with near-perfect complementarity to the target mRNA. Many plant miRNAs downregulate gene expression through this mechanism.
Synonyms:
  • gene silencing by miRNA, mRNA cleavage
  • miRNA-mediated gene silencing, mRNA cleavage
Proteins in PDR annotated with:
   This term: 11 [Search]
   Term or descendants: 11 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0035279 - mRNA cleavage involved in gene silencing by miRNA (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle