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Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA. The process by which microRNAs (miRNAs) block the translation of target mRNAs into proteins. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA will typically repress translation if the miRNA imperfectly base-pairs with the 3' untranslated regions of target mRNAs. Any process, mediated by small non-coding RNAs, that stops, prevents or reduces the rate that mRNAs are effectively translated into protein. Any process, mediated by small non-coding RNAs, that modulates the frequency, rate or extent that mRNAs are effectively translated into protein. Downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: mRNA cleavage or translational repression. Any process of posttranscriptional gene inactivation (silencing) mediated by small RNA molecules that may trigger mRNA degradation or negatively regulate translation.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of translation involved in gene silencing by miRNA
Acc: GO:0035278
Aspect: Biological Process
Desc: The process by which microRNAs (miRNAs) block the translation of target mRNAs into proteins. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA will typically repress translation if the miRNA imperfectly base-pairs with the 3' untranslated regions of target mRNAs.
Synonyms:
  • gene silencing by miRNA, negative regulation of translation
  • inhibition of translation involved in gene silencing by miRNA
  • down regulation of translation involved in gene silencing by miRNA
  • down-regulation of translation involved in gene silencing by miRNA
  • miRNA-mediated gene silencing, negative regulation of translation
  • downregulation of translation involved in gene silencing by miRNA
Proteins in PDR annotated with:
   This term: 6 [Search]
   Term or descendants: 6 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0035278 - negative regulation of translation involved in gene silencing by miRNA (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle