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Any process that activates or increases the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Any process that modulates the activity of glutamate-cysteine ligase. Any process that modulates the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. Any process that activates or increases the activity of glutamate-cysteine ligase, typically by lowering its sensitivity to inhibition by glutathione and by increasing its affinity for glutamate. Any process that activates or increases the activity of an enzyme.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: positive regulation of glutamate-cysteine ligase activity
Acc: GO:0035229
Aspect: Biological Process
Desc: Any process that activates or increases the activity of glutamate-cysteine ligase, typically by lowering its sensitivity to inhibition by glutathione and by increasing its affinity for glutamate.
Synonyms:
  • up regulation of glutamate-cysteine ligase activity
  • up-regulation of glutamate-cysteine ligase activity
  • stimulation of glutamate-cysteine ligase activity
  • activation of glutamate-cysteine ligase activity
  • upregulation of glutamate-cysteine ligase activity
Proteins in PDR annotated with:
   This term: 5 [Search]
   Term or descendants: 5 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0035229 - positive regulation of glutamate-cysteine ligase activity (interactive image map)

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