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Cleavage of double-stranded RNA molecules by an RNaseIII-family enzyme to produce small RNAs (generally 20-30 nucleotides, depending on species) with biological function. Cleavage of stem-loop RNA precursors into microRNAs (miRNAs), a class of small RNAs that primarily silence genes by blocking the translation of mRNA transcripts into protein. Any process involved in the conversion of a pre-microRNA transcript into a mature microRNA molecule. Downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: mRNA cleavage or translational repression. Any process involved in the conversion of a primary microRNA transcript into a pre-microRNA molecule. Any process of posttranscriptional gene inactivation (silencing) mediated by small RNA molecules that may trigger mRNA degradation or negatively regulate translation. Any process by which RNA molecules inactivate expression of target genes. The process by which a double-stranded RNA precursor is processed into short (20-30 nt) fragments. RNA cleavage is catalyzed by a Dicer endonuclease.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: production of miRNAs involved in gene silencing by miRNA
Acc: GO:0035196
Aspect: Biological Process
Desc: Cleavage of stem-loop RNA precursors into microRNAs (miRNAs), a class of small RNAs that primarily silence genes by blocking the translation of mRNA transcripts into protein.
Synonyms:
  • microRNA biosynthetic process
  • gene silencing by miRNA, production of miRNAs
  • microRNA biogenesis
  • miRNA processing
  • GO:0030918
  • microRNA biosynthesis
  • miRNA biogenesis
  • microRNA metabolism
  • microRNA metabolic process
  • microRNA processing
  • miRNA-mediated gene silencing, production of miRNAs
  • microRNA-mediated gene silencing, production of microRNAs
Proteins in PDR annotated with:
   This term: 22 [Search]
   Term or descendants: 44 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0035196 - production of miRNAs involved in gene silencing by miRNA (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle