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The process by which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes. Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript. Downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: mRNA cleavage or translational repression. Any process of posttranscriptional gene inactivation (silencing) mediated by small RNA molecules that may trigger mRNA degradation or negatively regulate translation. Any process that modulates the frequency, rate or extent of gene expression; the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence. Any transcriptional or post-transcriptional process carried out at the cellular level that results in long-term gene inactivation. Any process by which RNA molecules inactivate expression of target genes. The inactivation of gene expression by a posttranscriptional mechanism.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: posttranscriptional gene silencing by RNA
Acc: GO:0035194
Aspect: Biological Process
Desc: Any process of posttranscriptional gene inactivation (silencing) mediated by small RNA molecules that may trigger mRNA degradation or negatively regulate translation.
Synonyms:
  • RNA-mediated posttranscriptional gene silencing
  • sense-PTGS
Proteins in PDR annotated with:
   This term: 8 [Search]
   Term or descendants: 207 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0035194 - posttranscriptional gene silencing by RNA (interactive image map)
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