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The process by which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes. The process by which a single-stranded small RNA associates with the RNA-initiated silencing complex (RISC); occurs as part of a process of gene silencing by small RNA. The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex. Any process of posttranscriptional gene inactivation (silencing) mediated by small RNA molecules that may trigger mRNA degradation or negatively regulate translation. Any process by which RNA molecules inactivate expression of target genes. The transfer of small interfering RNA molecules (siRNAs) from the Dicer family of enzymes that cleave the double-stranded RNA, onto the nuclease-containing RNA-initiated silencing complex (RISC), in the context of RNA interference.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: siRNA loading onto RISC involved in RNA interference
Acc: GO:0035087
Aspect: Biological Process
Desc: The transfer of small interfering RNA molecules (siRNAs) from the Dicer family of enzymes that cleave the double-stranded RNA, onto the nuclease-containing RNA-initiated silencing complex (RISC), in the context of RNA interference.
Synonyms:
  • RNA interference, siRNA loading onto RISC
Proteins in PDR annotated with:
   This term: 20 [Search]
   Term or descendants: 20 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0035087 - siRNA loading onto RISC involved in RNA interference (interactive image map)
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