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Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. Catalysis of the reaction: a phospholipid + H2O = a lipid + phosphate. Catalysis of the removal of a phosphate group from phosphorylated myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol. Catalysis of the removal the of the 4-phosphate group of a phosphatidylinositol phosphate. Catalysis of the reaction: 1-phosphatidyl-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate. Catalysis of the removal of one of the two phosphate groups of a phosphatidylinositol bisphosphate.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: phosphatidyl-inositol-4,5-bisphosphate 4-phosphatase activity
Acc: GO:0034597
Aspect: Molecular Function
Desc: Catalysis of the reaction: 1-phosphatidyl-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate.
Synonyms:
  • phosphatidyl-myo-inositol-4,5-bisphosphate 4-phosphohydrolase activity
  • 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 4-phosphohydrolase activity
  • D-myo-inositol-4,5-bisphosphate 4-phosphohydrolase activity
  • inositol polyphosphate 4-phosphatase type II activity
Proteins in PDR annotated with:
   This term: 3 [Search]
   Term or descendants: 3 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0034597 - phosphatidyl-inositol-4,5-bisphosphate 4-phosphatase activity (interactive image map)
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