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The outer, i.e. cytoplasm-facing in a cellular organelle, lipid bilayer of an organelle envelope. Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope. A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together. Any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. Any constituent part of a mitochondrial membrane, either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope. The lipid bilayer surrounding the endoplasmic reticulum. A zone of apposition between the membranes of two organelles, structured by bridging complexes. Membrane contact sites (MCSs) are specialized for communication, including the efficient traffic of small molecules such as Ca2+ ions and lipids, as well as enzyme-substrate interactions. A zone of apposition between endoplasmic-reticulum and mitochondrial membranes, structured by bridging complexes. These contact sites are thought to facilitate inter-organelle calcium and phospholipid exchange. The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. A protein complex that links the endoplasmic reticulum with mitochondria and may have a role in promoting exchange of calcium and phospholipids between the two organelles. The complex is also associated with actively replicating mitochondrial DNA nucleoids, and may further coordinate mitochondrial genome replication and membrane growth.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: ERMES complex
Acc: GO:0032865
Aspect: Cellular Component
Desc: A protein complex that links the endoplasmic reticulum with mitochondria and may have a role in promoting exchange of calcium and phospholipids between the two organelles. The complex is also associated with actively replicating mitochondrial DNA nucleoids, and may further coordinate mitochondrial genome replication and membrane growth.
Synonyms:
  • Mdm10/Mdm12/Mmm1 complex
  • ER-mitochondria encounter structure
Proteins in PDR annotated with:
   This term: 8 [Search]
   Term or descendants: 8 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0032865 - ERMES complex (interactive image map)
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