YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. A heterodimeric protein complex formed of Spt4 and Spt5 proteins which is expressed in eukaryotes from yeast to man. DSIF is an inhibitory elongation factor that promotes RNA polymerase II transcriptional pausing, but can also stimulate transcriptional elongation under certain conditions, and may play a role in RNA processing via its physical association with mRNA capping enzymes. Any constituent part of the nucleoplasm, that part of the nuclear content other than the chromosomes or the nucleolus. Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: DSIF complex
Acc: GO:0032044
Aspect: Cellular Component
Desc: A heterodimeric protein complex formed of Spt4 and Spt5 proteins which is expressed in eukaryotes from yeast to man. DSIF is an inhibitory elongation factor that promotes RNA polymerase II transcriptional pausing, but can also stimulate transcriptional elongation under certain conditions, and may play a role in RNA processing via its physical association with mRNA capping enzymes.
Synonyms:
  • 5,6-Dichloro-1-beta-D-ribofuranosylbenzimidazole sensitivity inducing factor complex
  • DRB sensitivity inducing factor complex
  • Spt4-Spt5 complex
  • Spt5-Spt4 complex
Proteins in PDR annotated with:
   This term: 6 [Search]
   Term or descendants: 6 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0032044 - DSIF complex (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle