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A cell cycle checkpoint that monitors and signals errors in the placement or orientation of the spindle in the cell. The result is a cell cycle delay, usually in mitosis, until errors are corrected. A signal transduction-based surveillance mechanism that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage. A cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle. A cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: mitotic cell cycle spindle orientation checkpoint
Acc: GO:0031578
Aspect: Biological Process
Desc: A cell cycle checkpoint that monitors and signals errors in the placement or orientation of the spindle in the cell. The result is a cell cycle delay, usually in mitosis, until errors are corrected.
Synonyms:
  • spindle position checkpoint
  • SOC
  • SPOC
Proteins in PDR annotated with:
   This term: 8 [Search]
   Term or descendants: 8 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0031578 - mitotic cell cycle spindle orientation checkpoint (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle