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A cascade of processes induced by the detection of DNA damage within a cell. A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the initiation of apoptosis (programmed cell death). A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage. The series of molecular events whereby information is sent from one location to another within a cell. Any process that activates, maintains or increases the rate of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage. Any process that stops, prevents or reduces the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage. Any process that modulates the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage. A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, resulting in the induction of the transcription of p21 (also known as WAF1, CIP1 and SDI1) or any equivalent protein, in response to the detection of DNA damage. A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the stopping or reduction in rate of the cell cycle.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: DNA damage response, signal transduction by p53 class mediator
Acc: GO:0030330
Aspect: Biological Process
Desc: A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.
Synonyms:
  • GO:0006976
  • p53 signaling pathway
  • TP53 signaling pathway
  • DNA damage response, activation of p53
  • p53-mediated DNA damage response
Proteins in PDR annotated with:
   This term: 17 [Search]
   Term or descendants: 85 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0030330 - DNA damage response, signal transduction by p53 class mediator (interactive image map)
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