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A process that is carried out at the cellular level which results in the disassembly of the nucleus and contributes to apoptosis. The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments. A cellular process that results in the breakdown of a part of the cell. The compaction of chromatin during apoptosis. The breakdown of the nucleus into small membrane-bounded compartments, or blebs, each of which contain compacted DNA. A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. The breakdown of structures such as organelles, proteins, or other macromolecular structures during apoptosis.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: apoptotic nuclear change
Acc: GO:0030262
Aspect: Biological Process
Desc: A process that is carried out at the cellular level which results in the disassembly of the nucleus and contributes to apoptosis.
Proteins in PDR annotated with:
   This term: 5 [Search]
   Term or descendants: 52 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0030262 - apoptotic nuclear change (interactive image map)
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