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The process that regulates the coordinated growth and differentiation that establishes the non-random dorsal-ventral spatial arrangement of the spinal cord. The series of molecular signals initiated by binding of a ligand to the transmembrane receptor smoothened in a precursor cell in the ventral spinal cord that contributes to the commitment of the precursor cell to an interneuron fate. The process whereby the developmental fate of a cell becomes restricted such that it will develop into a ventral spinal cord interneuron. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened that results in the spatial identity of regions along the dorsal-ventral axis of the spinal cord. The process whereby a cell becomes capable of differentiating autonomously into a ventral spinal cord interneuron in an environment that is neutral with respect to the developmental pathway. The process whereby a cell becomes capable of differentiating autonomously into a neuron in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: smoothened signaling pathway involved in ventral spinal cord interneuron specification
Acc: GO:0021775
Aspect: Biological Process
Desc: The series of molecular signals initiated by binding of a ligand to the transmembrane receptor smoothened in a precursor cell in the ventral spinal cord that contributes to the commitment of the precursor cell to an interneuron fate.
Synonyms:
  • smoothened signalling pathway involved in ventral spinal cord interneuron specification
  • hh signaling pathway involved in ventral spinal cord interneuron specification
  • hedgehog signaling pathway involved in ventral spinal cord interneuron specification
Proteins in PDR annotated with:
   This term: 3 [Search]
   Term or descendants: 3 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0021775 - smoothened signaling pathway involved in ventral spinal cord interneuron specification (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle