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The series of molecular signals initiated by binding of a ligand to the transmembrane receptor smoothened in a precursor cell in the spinal cord that contributes to the process of a precursor cell becoming capable of differentiating autonomously into a motor neuron in an environment that is neutral with respect to the developmental pathway. The process whereby neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate. The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. The process whereby a cell becomes capable of differentiating autonomously into a motor neuron in an environment that is neutral with respect to the developmental pathway. The process whereby a cell becomes capable of differentiating autonomously into a neuron in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. The process whereby a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system. The process whereby the developmental fate of a cell becomes restricted such that it will develop into a neuron. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results the commitment of a cell to become a motor neuron in the ventral spinal cord. The process whose specific outcome is the progression of the ventral region of the spinal cord over time, from its formation to the mature structure. The neurons of the ventral region of the mature spinal cord participate in motor output. The process whereby relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: spinal cord motor neuron cell fate specification
Acc: GO:0021520
Aspect: Biological Process
Desc: The process whereby a cell becomes capable of differentiating autonomously into a motor neuron in an environment that is neutral with respect to the developmental pathway.
Proteins in PDR annotated with:
   This term: 6 [Search]
   Term or descendants: 12 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0021520 - spinal cord motor neuron cell fate specification (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle