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The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. The action characteristic of adrenocorticotropin-releasing hormone (CRH), any of a number of peptides released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, CRH increases the rate of adrenocorticotropin secretion by the anterior pituitary.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: adrenocorticotropin-releasing hormone activity
Acc: GO:0017045
Aspect: Molecular Function
Desc: The action characteristic of adrenocorticotropin-releasing hormone (CRH), any of a number of peptides released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, CRH increases the rate of adrenocorticotropin secretion by the anterior pituitary.
Synonyms:
  • corticotropin-releasing hormone
Proteins in PDR annotated with:
   This term: 2 [Search]
   Term or descendants: 2 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0017045 - adrenocorticotropin-releasing hormone activity (interactive image map)
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Created and Maintained by: Michael Riffle