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The process whereby a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. The process whereby a signal is passed from the insulin receptor to components of the phosphoinositide 3-kinase (PI3K) cascade, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. The series of molecular events whereby information is sent from one location to another within a cell. Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphoinositide 3-kinase cascade. Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction mediated by the phosphoinositide 3-kinase cascade. Any process that modulates the frequency, rate or extent of signal transduction mediated by the phosphoinositide 3-kinase cascade. A series of reactions, mediated by the intracellular phosphoinositide 3-kinase (PI3K). PI3K cascades lie downstream of many cell surface receptor linked signaling pathways and regulate numerous cellular functions.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: phosphoinositide 3-kinase cascade
Acc: GO:0014065
Aspect: Biological Process
Desc: A series of reactions, mediated by the intracellular phosphoinositide 3-kinase (PI3K). PI3K cascades lie downstream of many cell surface receptor linked signaling pathways and regulate numerous cellular functions.
Synonyms:
  • PI3K cascade
  • PI 3-kinase cascade
Proteins in PDR annotated with:
   This term: 17 [Search]
   Term or descendants: 58 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0014065 - phosphoinositide 3-kinase cascade (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle