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The process whereby a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. Any process that modulates the frequency, rate or extent of striated muscle cell differentiation. Any process that modulates the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast. Any process that modulates the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process whereby a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. Any process that stops, prevents or reduces the frequency, rate or extent of striated muscle cell differentiation. Any process that decreases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process whereby a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. Any process that stops, prevents or reduces the frequency, rate or extent of muscle cell differentiation. The process whereby a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of myotube differentiation
Acc: GO:0010832
Aspect: Biological Process
Desc: Any process that decreases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process whereby a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.
Proteins in PDR annotated with:
   This term: 6 [Search]
   Term or descendants: 6 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0010832 - negative regulation of myotube differentiation (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle