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Catalysis of the reaction: ATP + dihydropterate + L-glutamate = ADP + phosphate + dihydrofolate. Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. Catalysis of the ligation of two substances via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: dihydrofolate synthase activity
Acc: GO:0008841
Aspect: Molecular Function
Desc: Catalysis of the reaction: ATP + dihydropterate + L-glutamate = ADP + phosphate + dihydrofolate.
Synonyms:
  • dihydrofolate synthetase-folylpolyglutamate synthetase activity
  • dihydropteroate:L-glutamate ligase (ADP-forming) activity
  • H2-folate synthetase activity
  • 7,8-dihydropteroate:L-glutamate ligase (ADP) activity
  • DHFS activity
  • H(2)-folate synthetase activity
  • 7,8-dihydropteroate:L-glutamate ligase (ADP-forming)
  • FHFS activity
  • dihydrofolate synthetase activity
  • folylpoly-(gamma-glutamate) synthetase-dihydrofolate synthase activity
  • 7,8-dihydrofolate synthetase activity
  • FHFS/FPGS activity
Proteins in PDR annotated with:
   This term: 12 [Search]
   Term or descendants: 12 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0008841 - dihydrofolate synthase activity (interactive image map)

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