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A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. The morphological and physiological alterations undergone by mitochondria during apoptosis. The process by which enzymes, such as aspartate aminotransferase, are enabled to move from the mitochondrial matrix into the cytosol. The process by which a protein is incorporated into a mitochondrial membrane as an early step in apoptosis. A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. The process by which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation. A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components. Cell death resulting from activation of endogenous cellular processes. The change in the morphology of the mitochondria in an apoptotic cell from a highly branched network to a fragmented vesicular form.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: apoptotic mitochondrial changes
Acc: GO:0008637
Aspect: Biological Process
Desc: The morphological and physiological alterations undergone by mitochondria during apoptosis.
Proteins in PDR annotated with:
   This term: 14 [Search]
   Term or descendants: 59 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0008637 - apoptotic mitochondrial changes (interactive image map)
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