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Catalysis of the hydrolysis of a pyrophosphate bond between two phosphate groups, leaving one phosphate on each of the two fragments. Catalysis of the reaction: H2O + a nucleoside triphosphate = pyrophosphate + a nucleotide. Catalysis of the reaction: 8-oxo-7,8-dihydroguanosine triphosphate (8-Oxo-GTP) = 8-oxo-7,8-dihydroguanosine phosphate (8-Oxo-GMP) + diphosphate. 8-Oxo-GTP is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for transcription.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
Acc: GO:0008413
Aspect: Molecular Function
Desc: Catalysis of the reaction: 8-oxo-7,8-dihydroguanosine triphosphate (8-Oxo-GTP) = 8-oxo-7,8-dihydroguanosine phosphate (8-Oxo-GMP) + diphosphate. 8-Oxo-GTP is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for transcription.
Synonyms:
  • 8-oxo-7,8-dihydroguanosine triphosphatase activity
  • 7,8-dihydro-8-oxoguanine-triphosphatase activity
  • 8-oxo-GTPase activity
  • 8-oxo-7,8-dihydroguanine triphosphatase activity
Proteins in PDR annotated with:
   This term: 15 [Search]
   Term or descendants: 15 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0008413 - 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity (interactive image map)
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