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The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part. The process by which a fluid solution, or part of it, changes into a solid or semisolid mass. The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers. A pathway of blood coagulation that occurs during the clotting of platelet-poor plasma, in which activation of factor X to factor Xa is effected by the combination of factor IXa + factor VIIIa + calcium ion + phospholipid. The series of events that restore integrity to a damaged tissue, following an injury.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: blood coagulation, intrinsic pathway
Acc: GO:0007597
Aspect: Biological Process
Desc: A pathway of blood coagulation that occurs during the clotting of platelet-poor plasma, in which activation of factor X to factor Xa is effected by the combination of factor IXa + factor VIIIa + calcium ion + phospholipid.
Proteins in PDR annotated with:
   This term: 4 [Search]
   Term or descendants: 4 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0007597 - blood coagulation, intrinsic pathway (interactive image map)
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