YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

The process whereby a signal is conveyed via the transfer of one or more phosphate groups. The process of introducing a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein. The process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it. The formation of a dimer of two STAT proteins (Signal Transducers and Activators of Transcription) following their activation by members of the janus activated kinase (JAK) family of tyrosine kinases. The transport of dimerized STAT (Signal Transducers and Activators of Transcription) proteins into the nucleus following activation by members of the janus activated kinase (JAK) family of tyrosine kinases. Any process that modulates the frequency, rate or extent of the JAK-STAT signaling pathway. The process by which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of physiological ligands to the growth hormone receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes. Any process by which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of cytokines to their cognate receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes. The process of introducing a phosphate group to a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein. A series of reactions that occur within the cell, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound. Any process that stops, prevents or reduces the frequency, rate or extent of the JAK-STAT signaling pathway activity. Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity. The process whereby a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: JAK-STAT cascade
Acc: GO:0007259
Aspect: Biological Process
Desc: Any process by which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of cytokines to their cognate receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes.
Proteins in PDR annotated with:
   This term: 55 [Search]
   Term or descendants: 137 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0007259 - JAK-STAT cascade (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle