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The hydrolysis of a peptide bond or bonds within a protein as part of protein maturation, the process leading to the attainment of the full functional capacity of a protein. The proteolytic cleavages to the Notch protein that occur as a result of ligand binding. Ligand binding at the cell surface exposes an otherwise inaccessible cleavage site in the extracellular portion of Notch, which when cleaved releases a membrane-tethered form of the Notch intracellular domain. Subsequent cleavage within the transmembrane domain then leads to the release of the soluble Notch intracellular domain (NICD). The series of successive proteolytic cleavages of the Notch protein, which result in an active form of the receptor. The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell. Any protein maturation process achieved by the cleavage of peptide bonds. Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell. The proteolytic cleavages to the Notch protein that occur prior to ligand binding. A primary cleavage event within the extracellular domain whilst the Notch protein in still in the secretory pathway, leads to the transportation of a processed heterodimer to the cell surface.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: Notch receptor processing
Acc: GO:0007220
Aspect: Biological Process
Desc: The series of successive proteolytic cleavages of the Notch protein, which result in an active form of the receptor.
Synonyms:
  • N receptor processing
Proteins in PDR annotated with:
   This term: 12 [Search]
   Term or descendants: 12 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0007220 - Notch receptor processing (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle