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Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway. Any process of the immune system that occurs as part of an immune response. An immune response mediated by immunoglobulins, whether cell-bound or in solution. Any process that activates or increases the frequency, rate or extent of complement activation by the classical pathway. Any process that initiates an immune response. An immune response mediated through a body fluid. Any process activating plasma proteins by proteolysis as part of an acute inflammatory response. Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes. Any process that stops, prevents or reduces the frequency, rate or extent of complement activation by the classical pathway. Any process that modulates the frequency, rate or extent of the classical pathway of complement activation. An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: complement activation, classical pathway
Acc: GO:0006958
Aspect: Biological Process
Desc: Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes.
Proteins in PDR annotated with:
   This term: 37 [Search]
   Term or descendants: 37 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0006958 - complement activation, classical pathway (interactive image map)
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