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The process of directing proteins towards a membrane, usually using signals contained within the protein. The targeting of proteins to a membrane that occurs after their translation. Some secretory proteins exhibit posttranslational transport into the endoplasmic reticulum (ER) lumen: they are synthesized in their entirety on free cytosolic ribosomes and then released into the cytosol, where they are bound by chaperones which keep them in an unfolded state, and subsequently are translocated across the ER membrane. The process of targeting specific proteins to particular membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif. The process by which a protein translocates through the ER membrane posttranslationally. A process by which a protein is transported to, or maintained in, a location within the endoplasmic reticulum. The process of directing proteins towards the endoplasmic reticulum (ER) using signals contained within the protein. One common mechanism uses a 16- to 30-residue signal sequence, typically located at the N-terminus of the protein and containing positively charged amino acids followed by a continuous stretch of hydrophobic residues, which directs the ribosome to the ER membrane and initiates transport of the growing polypeptide across the ER membrane. The process by which the signal sequence of a translated protein binds to and forms a complex with the Sec complex.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: posttranslational protein targeting to membrane
Acc: GO:0006620
Aspect: Biological Process
Desc: The targeting of proteins to a membrane that occurs after their translation. Some secretory proteins exhibit posttranslational transport into the endoplasmic reticulum (ER) lumen: they are synthesized in their entirety on free cytosolic ribosomes and then released into the cytosol, where they are bound by chaperones which keep them in an unfolded state, and subsequently are translocated across the ER membrane.
Synonyms:
  • SRP-independent protein-membrane targeting
  • posttranslational protein-membrane targeting
  • posttranslational membrane targeting
  • posttranslational protein membrane targeting
Proteins in PDR annotated with:
   This term: 13 [Search]
   Term or descendants: 23 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0006620 - posttranslational protein targeting to membrane (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle