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The aggregation, arrangement and bonding together of a set of components to form a protein complex. The process by which SRP binds to the signal peptide in a nascent protein, causing protein elongation to pause, during cotranslational membrane targeting. The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. The targeting of proteins to a membrane that occurs during translation. The transport of most secretory proteins, particularly those with more than 100 amino acids, into the endoplasmic reticulum lumen occurs in this manner, as does the import of some proteins into mitochondria. The process of directing proteins towards the endoplasmic reticulum (ER) using signals contained within the protein. One common mechanism uses a 16- to 30-residue signal sequence, typically located at the N-terminus of the protein and containing positively charged amino acids followed by a continuous stretch of hydrophobic residues, which directs the ribosome to the ER membrane and initiates transport of the growing polypeptide across the ER membrane. The aggregation, arrangement and bonding together of a set of components to form a protein complex, occurring at the level of an individual cell. The aggregation, arrangement and bonding together of a set of macromolecules to form a complex, carried out at the cellular level.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition
Acc: GO:0006617
Aspect: Biological Process
Desc: The process by which SRP binds to the signal peptide in a nascent protein, causing protein elongation to pause, during cotranslational membrane targeting.
Synonyms:
  • SRP-dependent cotranslational protein-membrane targeting, signal sequence recognition
  • signal sequence recognition during SRP-dependent cotranslational protein targeting to membrane
  • SRP-dependent cotranslational membrane targeting, signal sequence recognition
Proteins in PDR annotated with:
   This term: 22 [Search]
   Term or descendants: 22 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0006617 - SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition (interactive image map)
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Created and Maintained by: Michael Riffle