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The ADP-ribosylation by a protein of one or more of its own amino acid residues, or residues on an identical protein. The transfer, from NAD, of ADP-ribose to protein amino acids. The transfer of multiple ADP-ribose residues from NAD to a protein amino acid, forming a poly(ADP-ribose) chain. This modification produces peptidyl-glutamic acid poly-ADP-ribose found in a number of nuclear proteins under certain conditions including the repair of single strand DNA breaks. The activated form of the generating enzyme poly(ADP-ribose) polymerase is itself modified in this way. The transfer, from NAD, of ADP-ribose to peptidyl-asparagine to form peptidyl-N4-(ADP-ribosyl)-L-asparagine. The transfer, from NAD, of ADP-ribose to peptidyl-cysteine to form peptidyl-S-(ADP-ribosyl)-L-cysteine. Any process that modulates the frequency, rate or extent of protein amino acid ADP-ribosylation. Protein amino acid ADP-ribosylation is the transfer, from NAD, of ADP-ribose to protein amino acids. Any process that decreases the frequency, rate or extent of protein amino acid ADP-ribosylation. Protein amino acid ADP-ribosylation is the transfer, from NAD, of ADP-ribose to protein amino acids. The transfer, from NAD, of ADP-ribose to peptidyl-serine to form peptidyl-O-(ADP-ribosyl)-L-serine. The transfer, from NAD, of ADP-ribose to peptidyl-arginine to form omega-N-(ADP-ribosyl)-L-arginine. The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: protein amino acid ADP-ribosylation
Acc: GO:0006471
Aspect: Biological Process
Desc: The transfer, from NAD, of ADP-ribose to protein amino acids.
Proteins in PDR annotated with:
   This term: 65 [Search]
   Term or descendants: 72 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0006471 - protein amino acid ADP-ribosylation (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle